N-(3,4-dichlorophenyl)-N-ethyl-3-(1-methylpiperidin-4-yl)-propionamide

Base Information

Chemical Name:N-(3,4-dichlorophenyl)-N-ethyl-3-(1-methylpiperidin-4-yl)-propionamide
CAS No.:1212022-74-6
Molecular Formula:C₁₇H₂₄Cl₂N₂O
Molecular Weight:343.296
Hs Code.:

Synonyms:N-(3,4-dichlorophenyl)-N-ethyl-3-(1-methylpiperidin-4-yl)-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3,4-dichlorophenyl)-N-ethyl-3-(1-methylpiperidin-4-yl)-propionamide

Chemical Property:

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Technology Process of N-(3,4-dichlorophenyl)-N-ethyl-3-(1-methylpiperidin-4-yl)-propionamide

There total 4 articles about N-(3,4-dichlorophenyl)-N-ethyl-3-(1-methylpiperidin-4-yl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1212022-70-2
N-(3,4-Dichloro-phenyl)-N-ethyl-3-piperidin-4-yl-propionamide

: 1212022-74-6
N-(3,4-dichlorophenyl)-N-ethyl-3-(1-methylpiperidin-4-yl)-propionamide

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; water; at 20 ℃; for 20h;

Reference yield:

: 154775-43-6
3-(1-(tert-butoxycarbonyl)piperidin-4-yl)propanoic acid

: 1212022-74-6
N-(3,4-dichlorophenyl)-N-ethyl-3-(1-methylpiperidin-4-yl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetic acid / dichloromethane

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

2.2: 15 h / 20 °C

3.1: trifluoroacetic acid / 3 h / 20 °C

3.2: SCX ion exchange column

4.1: sodium tris(acetoxy)borohydride / dichloromethane; water / 20 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; mineral oil;

Reference yield:

: 95-76-1
m,p-dichloroaniline

: 1212022-74-6
N-(3,4-dichlorophenyl)-N-ethyl-3-(1-methylpiperidin-4-yl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetic acid / dichloromethane

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

2.2: 15 h / 20 °C

3.1: trifluoroacetic acid / 3 h / 20 °C

3.2: SCX ion exchange column

4.1: sodium tris(acetoxy)borohydride / dichloromethane; water / 20 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; mineral oil;