2-{(E)-2-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid isopropylamide

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Chemical Name:2-{(E)-2-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid isopropylamide
CAS No.:1374645-57-4
Molecular Formula:C₁₉H₂₀FN₅OS
Molecular Weight:385.465
Hs Code.:

Synonyms:2-{(E)-2-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid isopropylamide

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Chemical Property of 2-{(E)-2-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid isopropylamide

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Technology Process of 2-{(E)-2-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid isopropylamide

There total 6 articles about 2-{(E)-2-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid isopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1374645-76-7
2-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid

: 75-31-0
isopropylamine

: 1374645-57-4
2-{(E)-2-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid isopropylamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1374645-57-4
2-{(E)-2-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid isopropylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: water; tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -75 °C / Inert atmosphere

3.2: 1 h / -75 - 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexanes / 2 h / -75 °C / Inert atmosphere

4.2: 2 h / -75 °C

5.1: diethyl ether; methanol

6.1: sulfuric acid / 2 h / 160 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With n-butyllithium; sulfuric acid; tetrabutyl ammonium fluoride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; copper(l) iodide; In tetrahydrofuran; methanol; hexanes; diethyl ether; hexane; N,N-dimethyl-formamide;

Reference yield:

: 1374645-83-6
2-{2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-2-hydroxy-ethyl}-4-methyl-thiazole-5-carboxylic acid

: 1374645-57-4
2-{(E)-2-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid isopropylamide

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether; methanol

2: sulfuric acid / 2 h / 160 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With sulfuric acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; N,N-dimethyl-formamide;