4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester hydrochloride

Base Information

Chemical Name:4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester hydrochloride
CAS No.:1567835-77-1
Molecular Formula:C₂₉H₃₉N₃O₃*ClH
Molecular Weight:514.108
Hs Code.:

Synonyms:4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester hydrochloride

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Chemical Property of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester hydrochloride

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Technology Process of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester hydrochloride

There total 10 articles about 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114369-15-2
2-(4-bromophenyl)ethyl methanesulfonate

: 1567835-77-1
4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / 21 h / 80 °C / Inert atmosphere

2.1: potassium tert-butylate / N,N-dimethyl-formamide; toluene / 29 h / -2 - 100 °C / Inert atmosphere; Cooling

3.1: tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; zinc(II) fluoride / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

3.2: 22 h / 90 °C

4.1: hydrogenchloride / diethyl ether / 0 - 5 °C

With hydrogenchloride; zinc(II) fluoride; tri-tert-butyl phosphine; potassium tert-butylate; potassium carbonate; potassium iodide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In diethyl ether; N,N-dimethyl-formamide; toluene;

Reference yield:

: 95893-88-2
N-(β-ethoxyethyl)-o-nitroaniline

: 1567835-77-1
4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: 5%-palladium/activated carbon; hydrogen / ethanol / 3 h / 5 - 10 °C / 2250.23 - 3000.3 Torr

2.1: potassium tert-butylate / N,N-dimethyl-formamide; toluene / 29 h / -2 - 100 °C / Inert atmosphere; Cooling

3.1: tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; zinc(II) fluoride / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

3.2: 22 h / 90 °C

4.1: hydrogenchloride / diethyl ether / 0 - 5 °C

With hydrogenchloride; zinc(II) fluoride; tri-tert-butyl phosphine; 5%-palladium/activated carbon; potassium tert-butylate; hydrogen; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: ethyl 1-(4-bromophenethyl)piperidine-4-carboxylate fumarate

: 1567835-77-1
4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / toluene; water

2.1: potassium tert-butylate / N,N-dimethyl-formamide; toluene / 29 h / -2 - 100 °C / Inert atmosphere; Cooling

3.1: tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; zinc(II) fluoride / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

3.2: 22 h / 90 °C

4.1: hydrogenchloride / diethyl ether / 0 - 5 °C

With hydrogenchloride; zinc(II) fluoride; tri-tert-butyl phosphine; potassium tert-butylate; sodium hydrogencarbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In diethyl ether; water; N,N-dimethyl-formamide; toluene;