methyl (5-fluoro-1-{(Z)-4-[(fluoromethyl)sulfonyl]benzylidene}-2-methylinden-3-yl)acetate

Base Information

Chemical Name:methyl (5-fluoro-1-{(Z)-4-[(fluoromethyl)sulfonyl]benzylidene}-2-methylinden-3-yl)acetate
CAS No.:292617-20-0
Molecular Formula:C₂₁H₁₈F₂O₄S
Molecular Weight:404.434
Hs Code.:

Synonyms:methyl (5-fluoro-1-{(Z)-4-[(fluoromethyl)sulfonyl]benzylidene}-2-methylinden-3-yl)acetate

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Chemical Property of methyl (5-fluoro-1-{(Z)-4-[(fluoromethyl)sulfonyl]benzylidene}-2-methylinden-3-yl)acetate

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Technology Process of methyl (5-fluoro-1-{(Z)-4-[(fluoromethyl)sulfonyl]benzylidene}-2-methylinden-3-yl)acetate

There total 3 articles about methyl (5-fluoro-1-{(Z)-4-[(fluoromethyl)sulfonyl]benzylidene}-2-methylinden-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 292617-18-6
methyl (5-fluoro-1-{(Z)-4-[(fluoromethyl)sulfanyl]benzylidene}-2-methylinden-3-yl)acetate

: 292617-20-0
methyl (5-fluoro-1-{(Z)-4-[(fluoromethyl)sulfonyl]benzylidene}-2-methylinden-3-yl)acetate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1211/146080800128735926

Reference yield:

: 38194-50-2
Sulindac

: 292617-20-0
methyl (5-fluoro-1-{(Z)-4-[(fluoromethyl)sulfonyl]benzylidene}-2-methylinden-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂SO₄ / 6 h / Heating

2: 72 percent / (diethylamino)sulfur trifluoride; ZnBr₂ / CHCl₃ / 24 h / 20 °C

3: 75 percent / 3-chloroperoxybenzoic acid / tetrahydrofuran / 3 h / 20 °C

With diethylamino-sulfur trifluoride; sulfuric acid; 3-chloro-benzenecarboperoxoic acid; zinc dibromide; In tetrahydrofuran; chloroform;
DOI:10.1211/146080800128735926

Reference yield:

: 134439-52-4
methyl-[5-fluoro-1-{[4-(methanesulfinyl)phenyl]methylidene}-2-methyl-1H-inden-3-yl]acetate

: 292617-20-0
methyl (5-fluoro-1-{(Z)-4-[(fluoromethyl)sulfonyl]benzylidene}-2-methylinden-3-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / (diethylamino)sulfur trifluoride; ZnBr₂ / CHCl₃ / 24 h / 20 °C

2: 75 percent / 3-chloroperoxybenzoic acid / tetrahydrofuran / 3 h / 20 °C

With diethylamino-sulfur trifluoride; 3-chloro-benzenecarboperoxoic acid; zinc dibromide; In tetrahydrofuran; chloroform;
DOI:10.1211/146080800128735926