1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethane

Base Information

Chemical Name:1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethane
CAS No.:154698-97-2
Molecular Formula:C₂₈H₃₂O₂Si
Molecular Weight:428.646
Hs Code.:

Synonyms:1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethane

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Technology Process of 1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethane

There total 6 articles about 1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 154698-95-0
1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-<2-<(methoxymethyl)oxy>-4-methylphenyl>ethane

: 154698-97-2
1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethane

Guidance literature:: With boron trifluoride diethyl etherate; ethanethiol; In dichloromethane; 1.) -78 deg C, 30 min, 2.) -23 deg C, 1.5 h;
DOI:10.1021/jo00080a014

Reference yield:

: 57234-27-2
1-(methoxymethoxy)-3-methylbenzene

: 154698-97-2
1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethane

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / t-BuLi / diethyl ether; hexane / 0 °C / 1.) 2 h, 2.) 1 h

2: 94 percent / NaH / tris<2-(2-methoxyethoxy)ethyl>amine / tetrahydrofuran / 62 °C / 1.) 10 h, 2.) 1 h

3: 91 percent / EtSH, BF₃*Et₂O / CH₂Cl₂ / 1.) -78 deg C, 30 min, 2.) -23 deg C, 1.5 h

With boron trifluoride diethyl etherate; tert.-butyl lithium; sodium hydride; ethanethiol; Tris(3,6-dioxaheptyl)amine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo00080a014

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 154698-97-2
1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethane

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / imidazole, DMAP / dimethylformamide / 10 h / Ambient temperature

2: 97 percent / Me₃Al / CH₂Cl₂; hexane / 1.) -15 deg C, 30 min; room temp., 35 min, 2.) room temp., 2 h

3: 80 percent / t-BuLi / diethyl ether; hexane / 0 °C / 1.) 2 h, 2.) 1 h

4: 94 percent / NaH / tris<2-(2-methoxyethoxy)ethyl>amine / tetrahydrofuran / 62 °C / 1.) 10 h, 2.) 1 h

5: 91 percent / EtSH, BF₃*Et₂O / CH₂Cl₂ / 1.) -78 deg C, 30 min, 2.) -23 deg C, 1.5 h

With 1H-imidazole; dmap; boron trifluoride diethyl etherate; trimethylaluminum; tert.-butyl lithium; sodium hydride; ethanethiol; Tris(3,6-dioxaheptyl)amine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00080a014