4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxaldehyde

Base Information

• Chemical Name: 4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxaldehyde
• CAS No.: 124864-15-9
• Molecular Formula: C₁₆H₁₆FNO
• Molecular Weight: 257.308
• Mol file: 124864-15-9.mol

Synonyms:4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxaldehyde

Chemical Property of 4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxaldehyde

There total 6 articles about 4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

→ 4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxaldehyde (124864-15-9)

Guidance literature:

Reference yield:

4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinemethanol (122252-99-7) → 4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxaldehyde (124864-15-9)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; at -78 ℃; for 0.25h;

DOI:10.1021/jm00113a019

Reference yield:

(E)-4-(4-fluorophenyl)but-3-en-2-one (65300-29-0) → 4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxaldehyde (124864-15-9)

Guidance literature:

Multi-step reaction with 4 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: 22 percent / LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

With lithium aluminium tetrahydride; copper diacetate; oxalyl dichloride; ammonium acetate; sodium ethanolate; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;

DOI:10.1021/jm00113a019

upstream raw materials:

4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinemethanol

(E)-4-(4-fluorophenyl)but-3-en-2-one

4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxylic acid,ethyl ester

β-(4-Fluorophenyl)-α-(2-methyl-1-oxopropyl)-Δ-oxohexanoic acid, ethyl ester

Downstream raw materials:

(S)-4-[[[4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinyl]ethynyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

3-(2,2-Dibromoethenyl)-4-(4-fluorophenyl)-6-methyl-2-(1-methylethyl)pyridine