122252-99-7

Upstream product

• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 65300-29-0 4-(4-fluorophenyl)but-3-en-2-one 
• 459-57-4 4-fluorobenzaldehyde 
• 65300-29-0 (E)-4-(4-fluorophenyl)but-3-en-2-one 
• 122252-69-1 4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxylic acid,ethyl ester 

Downstream Products

• 123930-18-7 3-{(E)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-2-isopropyl-6-methyl-pyridine 
• 122253-66-1 3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-2-isopropyl-6-methyl-pyridine 
• 122253-45-6 [4-(4-Fluoro-phenyl)-2-isopropyl-6-methyl-pyridin-3-ylmethyl]-triphenyl-phosphonium; bromide 
• 122253-87-6 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-fluoro-phenyl)-2-isopropyl-6-methyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-ol 
• 122254-09-5 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-fluoro-phenyl)-2-isopropyl-6-methyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-one 
• 135426-63-0 (S)-4-[[[4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinyl]ethynyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt 
• 135426-40-3 3-(2,2-Dibromoethenyl)-4-(4-fluorophenyl)-6-methyl-2-(1-methylethyl)pyridine 
• 124864-15-9 4-(4-Fluorophenyl)-6-methyl-2-(1-methylethyl)-3-pyridinecarboxaldehyde 
• 122253-22-9 3-Bromomethyl-4-(4-fluoro-phenyl)-2-isopropyl-6-methyl-pyridine 

Relevant academic research and scientific papers

PYRIDINE ANCHORS FOR HMG-COA REDUCTASE INHIBITORS

Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the e

7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis

Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula STR1 in which A, B, D and E can have varied meanings, X is --CH2 --CH2 or --CH=CH--, and R is STR2 wherein R21 denotes hyd

Phosphorus-Containing Inhibitors of HMG-CoA Reductase. 2. Synthesis and Biological Activites of a Series of Substituted Pyrydynes Containing a Hydroxyphosphinyl Moiety

A series of 2,3,4,(5),6-substituted pyridines containing a hydroxyphosphinyl functionality have been prepared and were evaluated for their ability to inhibit the enzyme HMG-CoA reductase.Systematic substitution of both R1-R4 and X-Y

CERTAIN 7-[2,6-DIISOPROPYL-4-PHENYL-5-LOWER ALKOXYMETHYL-PYRID-3-YL]-3,5-DIHYDROXY-6-ENOATES AND DERIVATIVES USEFUL FOR TREATING CIRCULATORY DISEASES

Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula (I) in which A, B, D and E can have varied meanings, X is -CH2-CH2 or -CH=CH-, and R is wherein R21 denotes hydrogen or alkyl and R22 denotes hydrogen, denotes alkyl, aryl or aralkyl, or denotes a cation, and their oxidation products

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)