Acetyl-Ser-Asp-Lys-Pro

Base Information

• Chemical Name: Acetyl-Ser-Asp-Lys-Pro
• CAS No.: 127103-11-1
• Molecular Formula: C₂₀H₃₃N₅O₉
• Molecular Weight: 487.51
• DSSTox Substance ID: DTXSID30402957,DTXSID40861258
• Mol file: 127103-11-1.mol

Synonyms:Ac-SDKP;Ac-Ser-Asp-Lys-Pro;Ac-Ser-Asp-Lys-Pro-NH2;acetyl-N-Ser-Asp-Lys-Pro;acetyl-SDKP;acetyl-seryl-aspartyl-lysyl-prolinamide;acetyl-seryl-aspartyl-lysyl-proline;AcSDKP;AcSDKP-NH2;goralatide;N-acetyl-Ser-Asp-Lys-Pro;seraspenide

Chemical Property of Acetyl-Ser-Asp-Lys-Pro

Chemical Property:

• PSA: 238.93000
• LogP: 0.29140
• Storage Temp.: −20°C
• Water Solubility.: Soluble in water at 2mg/ml
• XLogP3: -5.4
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 14
• Exact Mass: 487.22782765
• Heavy Atom Count: 34
• Complexity: 776

Purity/Quality:

99%+, ^*data from raw suppliers

Ac-Ser-Asp-Lys-Pro-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC(CO)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)O
• Uses: N-Acetyl-Ser-Asp-Lys-Pro inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. It is a specific substrate for the N-terminal active site of angiotensin converting enzyme, which is responsible for its degradation in vivo.

Technology Process of Acetyl-Ser-Asp-Lys-Pro

There total 4 articles about Acetyl-Ser-Asp-Lys-Pro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

NAcSer(OBzl)DAsp(OBzl)Lys(Z)ProOBzl (127129-86-6) → AcSDDKP (127103-11-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00170a012

Reference yield:

N-Acetylimidazole (2466-76-4) → AcSDDKP (127103-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / triethylamine / dimethylformamide / Ambient temperature

2: H₂ / 10percent Pd/C / methanol; H₂O / 760 Torr / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00170a012

Reference yield:

BocS(OBzl)-D-D(OBzl)K(Z)P-OBzl (127103-29-1) → AcSDDKP (127103-11-1)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / Ambient temperature

2: 84 percent / triethylamine / dimethylformamide / Ambient temperature

3: H₂ / 10percent Pd/C / methanol; H₂O / 760 Torr / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00170a012

upstream raw materials:

NAcSer(OBzl)DAsp(OBzl)Lys(Z)ProOBzl

N-Acetylimidazole

BocS(OBzl)-D-D(OBzl)K(Z)P-OBzl

Refernces