PHORBOL 13,20-DIACETATE

Base Information Edit

Chemical Name:PHORBOL 13,20-DIACETATE
CAS No.:41621-85-6
Molecular Formula:C24H32 O8
Molecular Weight:448.513
Hs Code.:
Mol file:41621-85-6.mol

Synonyms:5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one,9a-(acetyloxy)-3-[(acetyloxy)methyl]-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b,9-trihydroxy-1,1,6,8-tetramethyl-,[1aR-(1aa,1bb,4ab,7aa,7ba,8a,9b,9aa)]-; Phorbol 13,20-diacetate

Suppliers and Price of PHORBOL 13,20-DIACETATE

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
PHORBOL-13,20-DIACETATE 98.00%
5MG
$ 502.63

Total 2 raw suppliers

Chemical Property of PHORBOL 13,20-DIACETATE Edit

Chemical Property:

Vapor Pressure:4.92E-16mmHg at 25°C
Boiling Point:583.3°C at 760 mmHg
Flash Point:194.4°C
PSA：130.36000
Density:1.34g/cm³
LogP:1.07170
Storage Temp.:?20°C

Purity/Quality:

98%Min ^*data from raw suppliers

PHORBOL-13,20-DIACETATE 98.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T+
Statements: 26/27/28-36/37/38
Safety Statements: 26-27-36/37/39-45

MSDS Files:: Total 1 MSDS from other Authors

Useful:

Technology Process of PHORBOL 13,20-DIACETATE

There total 22 articles about PHORBOL 13,20-DIACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 17673-25-5
phorbol

: 108-24-7
acetic anhydride

: 41621-85-6
Phorbol 13,20-diacetate

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; for 8h;
DOI:10.1055/s-1999-3656

Reference yield:

: C₂₇H₄₀O₈Si

: 41621-85-6
Phorbol 13,20-diacetate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃;
DOI:10.1038/nature17153

Reference yield:

: C₃₃H₅₇F₃O₈Si₃

: 41621-85-6
Phorbol 13,20-diacetate

Guidance literature:: Multi-step reaction with 14 steps

1.1: dmap / dichloromethane / 0 °C

2.1: triethylamine / N,N-dimethyl-formamide / 60 °C

3.1: methanol / Reflux

4.1: acetic acid; sodium cyanoborohydride / methanol / Reflux

5.1: chromium(VI) oxide; 3,5-dimethyl-1H-pyrazole / dichloromethane / 0 - 20 °C

6.1: trimethylsilylazide / 1,2-dichloro-ethane / 70 °C

6.2: 70 °C

7.1: bis(benzonitrile)palladium(II) dichloride; triphenyl-arsane; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 80 °C

8.1: pyridine hydrogenfluoride / tetrahydrofuran / 0 °C

9.1: Martins sulfurane / 1,2-dichloro-ethane / 60 °C

10.1: selenium(IV) oxide / benzene / 80 °C

11.1: sodium tetrahydroborate / methanol / -40 °C

12.1: dmap / dichloromethane

13.1: sodium tris(acetoxy)borohydride / benzene / Reflux

14.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

With 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; dmap; selenium(IV) oxide; sodium tetrahydroborate; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; Martins sulfurane; triphenyl-arsane; trimethylsilylazide; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; pyridine hydrogenfluoride; acetic acid; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; benzene; 7.1: |Stille Cross Coupling;
DOI:10.1038/nature17153