3-(4-BENZYLOXY-PHENYL)-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID ETHYL ESTER

Base Information

• Chemical Name: 3-(4-BENZYLOXY-PHENYL)-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID ETHYL ESTER
• CAS No.: 127132-32-5
• Molecular Formula: C23H29 N O5
• Molecular Weight: 399.487
• Hs Code.: 2924299090
• Mol file: 127132-32-5.mol

Synonyms:BOC-L-O-benzyltyrosineethyl ester; N-(tert-Butoxycarbonyl)-O-benzyltyrosine ethyl ester

Chemical Property of 3-(4-BENZYLOXY-PHENYL)-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID ETHYL ESTER

Chemical Property:

• PSA: 73.86000
• LogP: 4.65540
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 3-(4-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-BENZYLOXY-PHENYL)-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID ETHYL ESTER

There total 3 articles about 3-(4-BENZYLOXY-PHENYL)-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-(tert-butoxycarbonyl)-L-tyrosine ethyl ester (72594-77-5,1241680-28-3) + benzyl bromide (100-39-0) → ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-O-(phenylmethyl)-L-tyrosinate (127132-32-5)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Heating;

DOI:10.1021/jm00168a015

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-O-(phenylmethyl)-L-tyrosinate (127132-32-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 82.6 percent / NaHCO₃ / methanol; tetrahydrofuran / 20 h / Ambient temperature

2: 84 percent / K₂CO₃ / acetone / 6 h / Heating

With sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; acetone;

DOI:10.1021/jm00168a015

Reference yield:

L-tyrosine ethyl ester (949-67-7) → ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-O-(phenylmethyl)-L-tyrosinate (127132-32-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 82.6 percent / NaHCO₃ / methanol; tetrahydrofuran / 20 h / Ambient temperature

2: 84 percent / K₂CO₃ / acetone / 6 h / Heating

With sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; acetone;

DOI:10.1021/jm00168a015

upstream raw materials:

N-(tert-butoxycarbonyl)-L-tyrosine ethyl ester

benzyl bromide

di-tert-butyl dicarbonate

L-tyrosine ethyl ester

Downstream raw materials:

(S)-N-[3-Chloro-2-oxo-1-[[4-(phenylmethoxy)phenyl]methyl]propyl]carbamic acid 1,1-dimethylethyl ester

tert-butyl (1S)-2-[4-(benzyloxy)phenyl]-1-[(2S)-oxiranyl]ethylcarbamate

(2S,3S)-N-tert-butoxycarbonyl-3-amino-4-(4-benzyloxyphenyl)-1-chloro-2-hydroxybutane

tert-butyl (1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isobutylamino)propylcarbamate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 127132-32-5 3-(4-BENZYLOXY-PHENYL)-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID ETHYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send