[3-(Dimethylamino)-2-octadec-9-enoyloxypropyl] octadec-9-enoate

Base Information

Chemical Name:[3-(Dimethylamino)-2-octadec-9-enoyloxypropyl] octadec-9-enoate
CAS No.:127512-29-2
Molecular Formula:C41H77 N O4
Molecular Weight:648.067
Hs Code.:
DSSTox Substance ID:DTXSID10400693
Mol file:127512-29-2.mol

Synonyms:127512-29-2;[3-(dimethylamino)-2-octadec-9-enoyloxypropyl] octadec-9-enoate;DTXSID10400693;AKOS030241389;FT-0606429

Suppliers and Price of [3-(Dimethylamino)-2-octadec-9-enoyloxypropyl] octadec-9-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,2-Dioleoyloxy-3-(dimethylamino)propane
1g
$ 1355.00

Medical Isotopes, Inc.
1,2-Dioleoyloxy-3-(dimethylamino)propane
0.5 g
$ 1560.00

Cayman Chemical
1,2-Dioleoyl-3-dimethylammonium-propane ≥98%
100mg
$ 208.00

Cayman Chemical
1,2-Dioleoyl-3-dimethylammonium-propane ≥98%
10mg
$ 49.00

Cayman Chemical
1,2-Dioleoyl-3-dimethylammonium-propane ≥98%
5mg
$ 26.00

Cayman Chemical
1,2-Dioleoyl-3-dimethylammonium-propane ≥98%
50mg
$ 156.00

American Custom Chemicals Corporation
1,2-DIOLEOYLOXY-3-(DIMETHYLAMINO)PROPANE 95.00%
100MG
$ 739.20

American Custom Chemicals Corporation
1,2-DIOLEOYLOXY-3-(DIMETHYLAMINO)PROPANE 95.00%
1G
$ 1871.10

Ambeed
(Z)-3-(Dimethylamino)propane-1,2-diyldioleate 98%
250mg
$ 193.00

Ambeed
(Z)-3-(Dimethylamino)propane-1,2-diyldioleate 98%
100mg
$ 120.00

Total 14 raw suppliers

Chemical Property of [3-(Dimethylamino)-2-octadec-9-enoyloxypropyl] octadec-9-enoate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.476
Boiling Point:670.148°C at 760 mmHg
Flash Point:359.092°C
PSA：55.84000
Density:0.916g/cm³
LogP:12.07800
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
XLogP3:15.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:37
Exact Mass:647.58525994
Heavy Atom Count:46
Complexity:717

Purity/Quality:

99% ^*data from raw suppliers

1,2-Dioleoyloxy-3-(dimethylamino)propane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCCCC=CCCCCCCCC(=O)OCC(CN(C)C)OC(=O)CCCCCCCC=CCCCCCCCC
Description DODAP (18:1) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7).
Uses Cationic amphiphiles are being studied for their potential role in preparing liposomes for interaction with artificial and biological membranes and cellular transfection techniques. Cationic species with ester linkages to the hydrophobic portion are more easily degraded by recipient cells and more efficiently metabolized.

Technology Process of [3-(Dimethylamino)-2-octadec-9-enoyloxypropyl] octadec-9-enoate

There total 3 articles about [3-(Dimethylamino)-2-octadec-9-enoyloxypropyl] octadec-9-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

: 127512-29-2
(+/-)-N,N-dimethyl-N-[2,3-bis(9-(Z)-octadecanoyloxy)propyl]amine

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

Reference yield: 95.0%

: 112-77-6
(Z)-9-octadecenoyl chloride

: 623-57-4
3-(dimethylamino)-1,2-propanediol

: 127512-29-2
(+/-)-N,N-dimethyl-N-[2,3-bis(9-(Z)-octadecanoyloxy)propyl]amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -5 - 20 ℃; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; Large scale;