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623-57-4

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623-57-4 Usage

Chemical Properties

pale yellow solid

Uses

3-(Dimethylamino)-1,2-propanediol was used in the preparation of:synthetic cationic lipid, N-[1-(2,3-dioleyloxy)propyl-N,N,N-trimethylammonium chloride (DOTMA), used in DNA-transfection protocolindane-derived bis(oxazolines)

Check Digit Verification of cas no

The CAS Registry Mumber 623-57-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 3 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 623-57:
(5*6)+(4*2)+(3*3)+(2*5)+(1*7)=64
64 % 10 = 4
So 623-57-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H13NO2/c1-6(2)3-5(8)4-7/h5,7-8H,3-4H2,1-2H3/p+1/t5-/m1/s1

623-57-4 Well-known Company Product Price

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  • Aldrich

  • (210218)  3-(Dimethylamino)-1,2-propanediol  98%

  • 623-57-4

  • 210218-25ML

  • 837.72CNY

  • Detail

623-57-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(Dimethylamino)-1,2-propanediol

1.2 Other means of identification

Product number -
Other names 1,2-Propanediol, 3-(dimethylamino)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:623-57-4 SDS

623-57-4Relevant articles and documents

Interaction of doxorubicin hydrochloride in the presence of, mixed aggregate of ibuprofen sodium and cationic lipid

Li, Guanyi,Liu, Chenyu,Qiao, Weihong,Srivastava, Anirudh

, (2020/06/22)

This research was highlighted the importance of mixed aggregates based on drug-lipid to improve the interaction of one or more drugs in aqueous medium. This mixed aggregate can significantly inhibit the growth of MCF-7 cells, and has great potential for anti-inflammatory and cancer treatment after tumor removal. The cationic lipid (CL) has been synthesized with multistep reaction and is characterized by 1H NMR and mass spectroscopy. CL and ibuprofen (IBF) physiochemical analysis was investigated using surface tension, conductance, dynamic light scattering (DLS), and electron microscope transmission (TEM). The strong synergism between mixed aggregate (LIB) system CL and IBF was observed. The study on UV spectroscopy measured that the LIB mixed aggregate showed optimum binding to doxorubicin hydrochloride (DOX) and the binding constant Log Kb was 6.17 compared to single CL, the Log Kb was 5.83. Binding results indicated that the DOX was more encapsulated in mixed LIB aggregates compared to single CL aggregates. This mixed aggregate LIB has excellent performance in controlling the release of drugs. For single CL aggregate, approximately 62.5percent DOX was released after 72 h (pH = 7.4). However, LIB such as, (0.1αCL+ 0.9αIBF), the release of DOX decreased to 16.08percent. Finally, LIB mixed aggregate applicability has been used to minimize the cytotoxicity of MCF-7 cells, and it has been found that DOX in LIB mixed aggregates has a higher inhibitory effect on cell growth than DOX in CL.

Cationic alkyd polyesters for medical applications

-

, (2008/06/13)

The present invention is directed to medical devices or pharmaceutical composition, each containing a synthetic, biodegradable, biocompatible polymer that is the reaction product of a polybasic acid or derivative thereof, a monoglyceride, and a cationic polyol.

Process for the preparation of glyceraldehyde and derivatives thereof

-

, (2008/06/13)

The invention pertains to a process for the preparation of glyceraldehyde, or an acetal or a hemiacetal thereof, characterized in that 3-butene-1,2-diol is dissolved in a lower alkanol and is subjected to ozonolysis to obtain a 3-hydroperoxy-3-alkoxy-propane-1,2-diol, which is subjected to a reductive treatment to obtain a hemiacetal of glyceraldehyde, which optionally may be converted into glyceraldehyde or an acetal or hemiacetal thereof, and to a process wherein the hemiacetal of glyceraldehyde is converted to a 3-aminopropane-1,2-diol derivative, by subjecting the hemiacetal of glyceraldehyde to a reductive treatment in the presence of ammonia or a primary or secondary amine. Preferably, the hemiacetal of glyceraldehyde is subjected to a reductive treatment in the presence of an amine with the formula R1R2NH, wherein R1 and R2 independently are hydrogen or an alkyl group with 1-18 carbon atoms, or R1 and R2 together with the nitrogen atom to which they are bonded form a 5- or 6-membered ring, to give a compound with the formula R1R2N—CH2—CHOH—CH2OH, wherein R1 and R2 have the previously given meanings

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