2-AMINONORBORNANE HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINONORBORNANE HYDROCHLORIDE
• CAS No.: 14370-45-7
• Molecular Formula: C₇H₁₃N*ClH
• Molecular Weight: 147.648
• Hs Code.: 2921309990
• Mol file: 14370-45-7.mol

Synonyms:2-Norbornanamine,hydrochloride (7CI,8CI); Bicyclo[2.2.1]heptan-2-amine, hydrochloride (9CI);2-Aminonorbornane hydrochloride; 2-Norbornylamine hydrochloride; NSC 89711

Chemical Property of 2-AMINONORBORNANE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 2.44mmHg at 25°C
• Melting Point: 295 °C (dec.)(lit.)
• Boiling Point: 160°C at 760 mmHg
• Flash Point: 35°C
• PSA: 26.02000
• LogP: 2.63600
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bicyclo[2.2.1]heptan-2-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-AMINONORBORNANE HYDROCHLORIDE

There total 5 articles about 2-AMINONORBORNANE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

diethyl N-exo-norbornylphosphoramidate (85231-79-4) → (+/-)-exo-2-aminonorbornane hydrochloride (14370-45-7,39245-79-9,65481-69-8,111058-85-6,121055-08-1,121122-83-6,142344-61-4)

Guidance literature:

With hydrogenchloride; In benzene; Ambient temperature;

DOI:10.1055/s-1982-29995

Reference yield: 42.0%

bicyclo[2.2.1]heptan-2-one oxime (4576-48-1,49805-50-7,49805-51-8,141782-05-0) → (1R,4S)-Bicyclo[2.2.1]heptan-2-ol (497-36-9,497-37-0,1632-68-4,24325-44-8,29583-34-4,36779-79-0,60133-16-6,61277-90-5,61277-93-8) + (±)-endo-2-norbornylamine hydrochloride (14370-45-7,39245-79-9,65481-69-8,111058-85-6,121055-08-1,121122-83-6,142344-61-4)

Guidance literature:

bicyclo[2.2.1]heptan-2-one oxime; With NiAl₂; potassium hydroxide; In tetrahydrofuran; water; Reflux;

With hydrogenchloride; In tetrahydrofuran; tert-butyl methyl ether;

DOI:10.1134/S1070428019110162

Reference yield:

norborn-2-ene (498-66-8) → (+/-)-exo-2-aminonorbornane hydrochloride (14370-45-7,39245-79-9,65481-69-8,111058-85-6,121055-08-1,121122-83-6,142344-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Hg(NO₃)2, 2.) 10percent aq NaOH, NaBH₄ / 1.) CH₃CHCl₂, reflux, 15 h, 2.) room temp., 1 h

2: 83 percent / hydrogen chloride / benzene / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; mercury(II) nitrate; In benzene;

DOI:10.1055/s-1982-29995

upstream raw materials:

acide bicyclo<2.2.1>heptane carboxylique-2 exo

diethyl N-exo-norbornylphosphoramidate

norborn-2-ene

2-norbornanone

Downstream raw materials:

(1RS,4SR)-norcamphane-2-amine

N-(exo-norborn-2-yl)-N'-(2-iodophenyl)guanidine

N-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-N'-o-tolyl-guanidine

Refernces

• 1、 Koziara, Anna,Olejniczak, Bogdan,Osowska, Krystyna,Zwierzak, Andrzej. "Phosphoramidomercuration-Demercuration: A Simple, Two-Step Conversion of Alkenes into Alkanamines". . p. 918 - 920. Retrieved 2007/10/02.