(1R,2S)-Methyl 2-aminocyclopentanecarboxylate

Base Information

Chemical Name:(1R,2S)-Methyl 2-aminocyclopentanecarboxylate
CAS No.:128001-37-6
Molecular Formula:C₇H₁₃NO₂
Molecular Weight:143.186
Hs Code.:
European Community (EC) Number:828-965-0,835-700-2
DSSTox Substance ID:DTXSID30563138
Nikkaji Number:J386.429D
Wikidata:Q76423942
Mol file:128001-37-6.mol

Synonyms:(1R,2S)-Methyl 2-aminocyclopentanecarboxylate;154460-33-0;128001-37-6;Methyl cis-2-Aminocyclopentanecarboxylate;methyl (1R,2S)-2-aminocyclopentane-1-carboxylate;Cyclopentanecarboxylic acid, 2-amino-, methyl ester, (1R-cis)- (9CI);cis-Methyl-2-Aminocyclopentanecarboxylate;Cyclopentanecarboxylic acid, 2-amino-, methyl ester, (1R,2S)-rel-;rac-methyl (1R,2S)-2-aminocyclopentane-1-carboxylate;SCHEMBL1144485;DTXSID30563138;RGXCCQQWSIEIEF-RITPCOANSA-N;AKOS006347606;Methylcis-2-Aminocyclopentanecarboxylate;CS-11781;CS-0444174;(cis)-methyl 2-aminocyclopentane-1-carboxylate;EN300-243383;EN300-309478;methyl (1R,2S)-2-aminocyclopentanecarboxylate;N12552;A848186

Suppliers and Price of (1R,2S)-Methyl 2-aminocyclopentanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methylcis-2-Aminocyclopentanecarboxylate 95+%
10g
$ 1140.00

Chemenu
Methylcis-2-Aminocyclopentanecarboxylate 95%
10g
$ 1066.00

Chemenu
Methylcis-2-Aminocyclopentanecarboxylate 95%
5g
$ 684.00

Total 8 raw suppliers

Chemical Property of (1R,2S)-Methyl 2-aminocyclopentanecarboxylate

Chemical Property:

PSA：52.32000
LogP:0.98710
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:143.094628657
Heavy Atom Count:10
Complexity:136

Purity/Quality:

97% ^*data from raw suppliers

Methylcis-2-Aminocyclopentanecarboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1CCCC1N
Isomeric SMILES:COC(=O)[C@@H]1CCC[C@@H]1N

Technology Process of (1R,2S)-Methyl 2-aminocyclopentanecarboxylate

There total 2 articles about (1R,2S)-Methyl 2-aminocyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl cis-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopentanecarboxylate

: 128001-37-6,135053-21-3,170421-23-5
(1S,2R)-2-Amino-cyclopentanecarboxylic acid methyl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 ℃; for 2h;
DOI:10.1021/jo00023a033

Reference yield:

: 136315-70-3
(±)-cis-2-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid

: 128001-37-6,135053-21-3,170421-23-5
(1S,2R)-2-Amino-cyclopentanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 0 °C

2: 4 N HCl / dioxane / 2 h / 0 °C

With hydrogenchloride; In 1,4-dioxane; diethyl ether;
DOI:10.1021/jo00023a033

Reference yield:

: 3479-47-8
Z-Asp(OBzl)-OH

: 128001-37-6,135053-21-3,170421-23-5
(1S,2R)-2-Amino-cyclopentanecarboxylic acid methyl ester

: 136315-65-6
N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-cis-(1S,2R)-2-aminocyclopentanecarboxylic acid methyl ester

: 136237-68-8
N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-cis-(1R,2S)-2-aminocyclopentanecarboxylic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; Yield given. Yields of byproduct given. Title compound not separated from byproducts; pH 6 (Et₃N), 1) -30 deg C, 1 h, 2) r.t., 2 h;
DOI:10.1021/jo00023a033