1-(9H-FLUOREN-9-YL)PIPERAZINE

Base Information

• Chemical Name: 1-(9H-FLUOREN-9-YL)PIPERAZINE
• CAS No.: 129604-54-2
• Molecular Formula: C17H18 N2
• Molecular Weight: 250.343
• Hs Code.: 2933599090
• Mol file: 129604-54-2.mol

Synonyms:1-(9H-Fluoren-9-yl)piperazine;4-(9-Fluorenyl)piperazine; NSC 27145

Chemical Property of 1-(9H-FLUOREN-9-YL)PIPERAZINE

Chemical Property:

• Vapor Pressure: 1.11E-06mmHg at 25°C
• Refractive Index: 1.635
• Boiling Point: 402.2°C at 760 mmHg
• Flash Point: 175.7°C
• PSA: 15.27000
• Density: 1.161g/cm³
• LogP: 2.92830

Purity/Quality:

98%min ^*data from raw suppliers

1-(9H-Fluoren-9-yl)piperazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(9H-FLUOREN-9-YL)PIPERAZINE

There total 7 articles about 1-(9H-FLUOREN-9-YL)PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

piperazine (110-85-0) + 9H-fluoren-9-yl bromide (1940-57-4) → 1-(9H-fluoren-9-yl)-piperazine (129604-54-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 6h; Reflux; Inert atmosphere;

DOI:10.1016/j.ejmech.2015.06.035

Reference yield: 67.0%

piperazine (110-85-0) + 9-chlorofluorene (6630-65-5) → 1-(9H-fluoren-9-yl)-piperazine (129604-54-2)

Guidance literature:

In butanone; for 16h; Heating;

DOI:10.1021/jm060715y

Reference yield: 42.0%

4-(9H-fluoren-9-yl)piperazin-1-carboxaldehyde (1103929-95-8) → 1-(9H-fluoren-9-yl)-piperazine (129604-54-2)

Guidance literature:

4-(9H-fluoren-9-yl)piperazin-1-carboxaldehyde; With hydrogenchloride; water; In 1,4-dioxane; at 80 ℃; for 6h;

With ammonia; water;

upstream raw materials:

piperazine

9-chlorofluorene

4-(9H-fluoren-9-yl)piperazin-1-carboxaldehyde

9H-fluoren-9-yl bromide

Refernces

• 1、 Chollet, Aurélien,Mori, Giorgia,Menendez, Christophe,Rodriguez, Frédéric,Fabing, Isabelle,Pasca, Maria Rosalia,Madacki, Jan,Korduláková, Jana,Constant, Patricia,Quémard, Anna?k,Bernardes-Génisson, Vania,Lherbet, Christian,Baltas, Michel. "Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth". . p. 218 - 235. Retrieved 2015/07/07.
• 2、 He, Xin,Alian, Akram,Stroud, Robert,Ortiz De Montellano, Paul R.. "Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis". . p. 6308 - 6323. Retrieved 2007/10/03.