1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

Base Information

Chemical Name:1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride
CAS No.:129768-24-7
Molecular Formula:C6H4 Cl F3 N2 O
Molecular Weight:212.559
Hs Code.:2933199090
DSSTox Substance ID:DTXSID40563846
Wikidata:Q82448343
Mol file:129768-24-7.mol

Synonyms:1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride;129768-24-7;2-methyl-5-(trifluoromethyl)pyrazole-3-carbonyl chloride;1H-Pyrazole-5-carbonyl chloride, 1-methyl-3-(trifluoromethyl)- (9CI);1H-Pyrazole-5-carbonyl chloride, 1-methyl-3-(trifluoromethyl)-;SCHEMBL951323;DTXSID40563846;MFCD03421457;AKOS000308534;CS-0300529;EN300-228556;G72275;1-methyl-3-trifluoromethyl-1H-pyrazole-5-carbonyl chloride;2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride;1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonylchloride

Suppliers and Price of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride
5g
$ 1360.00

Matrix Scientific
1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride
500mg
$ 350.00

Matrix Scientific
1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride
1g
$ 454.00

Crysdot
1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonylchloride 95+%
1g
$ 450.00

CHESS?
MC003623:2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carbonylchloride 98
5 g
$ 780.00

Chemenu
1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonylchloride 95%
1g
$ 424.00

American Custom Chemicals Corporation
1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBONYL CHLORIDE 95.00%
500MG
$ 924.00

Total 4 raw suppliers

Chemical Property of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

Chemical Property:

PSA：34.89000
LogP:1.81790
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:211.9964249
Heavy Atom Count:13
Complexity:220

Purity/Quality:

98%min ^*data from raw suppliers

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=CC(=N1)C(F)(F)F)C(=O)Cl

Technology Process of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

There total 2 articles about 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128694-63-3
1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid

: 129768-24-7
1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1016/j.bmcl.2005.08.034

Reference yield:

: 154471-65-5
1-methyl-3-trifluoromethylpyrazol

: 129768-24-7
1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran

2.1: (COCl)2; DMF / CH₂Cl₂

With oxalyl dichloride; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.08.034