128694-63-3Relevant articles and documents
Direct [3+2]-cycloaddition of electron-deficient alkynes with CF3CHN2: Regioselective one-pot synthesis of 3-trifluoromethylpyrazoles
Li, Feng,Wang, Jingjing,Pei, Wenlong,Li, Hong,Zhang, Huiling,Song, Manman,Guo, Linyun,Zhang, Anan,Liu, Lantao
, p. 4344 - 4347 (2017)
A direct and facile cycloaddition reaction of electron-deficient terminal alkynes with 2,2,2-trifluorodiazoethane under mild conditions to afford a series of 5-substituted 3-trifluoromethylpyrazoles in high yields is described. The potential application of this cycloaddition reaction was demonstrated via the efficient synthesis of a key intermediate of the antiviral drug AS-136A and a fluorinated analog of Tebufenpyrad.
Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles
Chalyk, Bohdan A.,Khutorianskyi, Andrii,Lysenko, Andrii,Fil, Yulia,Kuchkovska, Yuliya O.,Gavrilenko, Konstantin S.,Bakanovych, Iulia,Moroz, Yurii S.,Gorlova, Alina O.,Grygorenko, Oleksandr O.
supporting information, p. 15212 - 15225 (2019/11/19)
A facile synthetic route toward either 3- or 5-fluoroalkyl-substituted isoxazoles or pyrazoles containing an additional functionalization site was developed and applied on a multigram scale. The elaborated approach extends the scope of fluoroalkyl substituents for introduction into the heterocyclic moiety, and uses convenient transformations of the side chain for incorporation of fluoroalkyl-substituted azoles into the structures of biologically active molecules. The utility of the obtained building blocks for isosteric replacement of alkyl-substituted isoxazole and pyrazole was shown by the synthesis of fluorinated Isocarboxazid and Mepiprazole analogues.
PARAMYXOVIRUS FAMILY INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 4; 11, (2011/07/08)
Embodiments of the present disclosure include methods for identifying a compound or compounds useful as therapeutic agents in the treatment of paramyxovirus infections, compounds for the treatment of measles, and high throughput screening methods for iden
