2H-1-Benzopyran-2-carbonylchloride,3,4-dihydro-,(2S)-(9CI)

Base Information

• Chemical Name: 2H-1-Benzopyran-2-carbonylchloride,3,4-dihydro-,(2S)-(9CI)
• CAS No.: 130049-78-4
• Molecular Formula: C₁₀H₉ClO₂
• Molecular Weight: 196.633
• Mol file: 130049-78-4.mol

Synonyms:2H-1-Benzopyran-2-carbonylchloride,3,4-dihydro-,(2S)-(9CI)

Chemical Property of 2H-1-Benzopyran-2-carbonylchloride,3,4-dihydro-,(2S)-(9CI)

Chemical Property:

• PSA: 26.30000
• LogP: 2.14560

Purity/Quality:

98%min ^*data from raw suppliers

(2S)-3,4-Dihydro-2H-1-benzopyran-2-carbonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2S)-3,4-Dihydro-2H-1-benzopyran-2-carbonyl Chloride is an intermediate used in the synthesis of (S)-9-Hydroxy Risperidone-d4 (H953362), which is the S-enantiomer metabolite of Risperidone (R525000), a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.

Technology Process of 2H-1-Benzopyran-2-carbonylchloride,3,4-dihydro-,(2S)-(9CI)

There total 2 articles about 2H-1-Benzopyran-2-carbonylchloride,3,4-dihydro-,(2S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-3,4-dihydro-2H-chromene-2-carboxylic acid (83780-46-5) → (S)-chroman-2-carbonyl chloride (130049-78-4)

Guidance literature:

With thionyl chloride; In 1,2-dichloro-ethane; at 0 ℃; for 1h; Reflux;

Reference yield:

→ (S)-chroman-2-carbonyl chloride (130049-78-4)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; at 0 - 20 ℃; Reflux;

upstream raw materials:

(2S)-3,4-dihydro-2H-chromene-2-carboxylic acid

Refernces

• 1、 -. "SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS". Page/Page column 49; 52. . Retrieved 2013/09/12.