83780-46-5

Basic information

• Product Name: (2S)-3,4-dihydro-2H-chromene-2-carboxylic acid
• Synonyms: (2S)-3,4-dihydro-2H-chromene-2-carboxylic acid
• CAS NO: 83780-46-5
• Molecular Weight: 178.188
• Mol File: 83780-46-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-3,4-dihydro-2H-chromene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-3,4-dihydro-2H-chromene-2-carboxylic acid(83780-46-5)
• EPA Substance Registry System: (2S)-3,4-dihydro-2H-chromene-2-carboxylic acid(83780-46-5)

Safety Data

• Hazardous Substances Data: 83780-46-5(Hazardous Substances Data)

Upstream product

• 24698-77-9 ethyl Chroman-2-carboxylate 

Downstream Products

• 130049-78-4 (S)-chroman-2-carbonyl chloride 
• 228710-74-5 6-{4-[4-(3-Cyclopentyl-propyl)-5-oxo-4,5-dihydro-tetrazol-1-yl]-phenylsulfamoyl}-chroman-(2S)-carboxylic acid isobutyl ester 
• 228710-81-4 6-{4-[4-(3-cyclopentyl-propyl)-5-oxo-4,5-dihydro-tetrazol-1-yl]-phenylsulfamoyl}-chroman-(S)-2-carboxylic acid 
• 66598-89-8 Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-(R)-3-chroman-2-yl-3-hydroxy-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 
• 66598-89-8 Biphenyl-4-carboxylic acid (3aR,5R,6aS)-4-((E)-(S)-3-chroman-2-yl-3-hydroxy-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 
• 66598-88-7 Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-3-chroman-2-yl-3-oxo-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 

Relevant articles and documents

New serotonin 5-HT1A receptor agonists with neuroprotective effect against ischemic cell damage

We report the synthesis of new compounds 4-35 based on structural modifications of different moieties of previously described lead UCM-2550. The new nonpiperazine derivatives, representing second-generation agonists, were assessed for binding affinity, selectivity, and functional activity at the 5-HT1A receptor (5-HT1AR). Computational β2-based homology models of the ligand-receptor complexes were used to explain the observed structure-affinity relationships. Selected candidates were also evaluated for their potential in vitro and in vivo neuroprotective properties. Interestingly, compound 26 (2-{6-[(3,4-dihydro-2H- chromen-2-ylmethyl)amino]hexyl}tetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H) -dione) has been characterized as a high-affinity and potent 5-HT1AR agonist (Ki = 5.9 nM, EC50 = 21.8 nM) and exhibits neuroprotective effect in neurotoxicity assays in primary cell cultures from rat hippocampus and in the MCAO model of focal cerebral ischemia in rats.