2-Propenoic acid, 2-[(methoxycarbonyl)methylamino]-, methyl ester

Base Information

• Chemical Name: 2-Propenoic acid, 2-[(methoxycarbonyl)methylamino]-, methyl ester
• CAS No.: 130291-56-4
• Molecular Formula: C7H11 N O4
• Molecular Weight: 173.17
• Mol file: 130291-56-4.mol

Synonyms:2-Propenoic acid, 2-[(methoxycarbonyl)methylamino]-, methyl ester

Chemical Property of 2-Propenoic acid, 2-[(methoxycarbonyl)methylamino]-, methyl ester

Chemical Property:

• PSA: 55.84000
• LogP: 0.37130

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 2-[(methoxycarbonyl)methylamino]-, methyl ester

There total 2 articles about 2-Propenoic acid, 2-[(methoxycarbonyl)methylamino]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-<(methoxycarbonyl)amino>-2-propenoic acid methyl ester (76637-56-4) + methyl iodide (74-88-4) → N-(Methoxycarbonyl)-N-methyldehydroalanine methyl ester (130291-56-4)

Guidance literature:

With silver(l) oxide; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 1h;

DOI:10.1021/jo00047a031

Reference yield:

N-(Methoxycarbonyl)-DL-serine methyl ester (143076-21-5) → N-(Methoxycarbonyl)-N-methyldehydroalanine methyl ester (130291-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / NEt₃, MsCl / CH₂Cl₂ / 1 h / Ambient temperature

2: 80 percent / Ag₂O / dimethylformamide / 1 h / 50 - 60 °C

With methanesulfonyl chloride; triethylamine; silver(l) oxide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00047a031

Reference yield: 75.0%

N-(Methoxycarbonyl)-N-methyldehydroalanine methyl ester (130291-56-4) + N-(p-Toluenesulfonyl)-3-(phenylthio)-2-piperidone (143076-20-4) → 2-(Methoxycarbonyl-methyl-amino)-3-[2-oxo-3-phenylsulfanyl-1-(toluene-4-sulfonyl)-piperidin-3-yl]-propionic acid methyl ester (130291-48-4)

Guidance literature:

With potassium hexamethylsilazane;

DOI:10.1016/S0040-4039(00)94730-0

upstream raw materials:

2-<(methoxycarbonyl)amino>-2-propenoic acid methyl ester

methyl iodide

N-(Methoxycarbonyl)-DL-serine methyl ester

Downstream raw materials:

2-(Methoxycarbonyl-methyl-amino)-3-[2-oxo-3-phenylsulfanyl-1-(toluene-4-sulfonyl)-piperidin-3-yl]-propionic acid methyl ester

Refernces