ETHYL 4-HYDROXY-5-OXO-1-(2-THIENYLMETHYL)-2,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 4-HYDROXY-5-OXO-1-(2-THIENYLMETHYL)-2,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLATE
• CAS No.: 131436-78-7
• Molecular Formula: C₁₂H₁₃NO₄S
• Molecular Weight: 267.306
• Hs Code.: 2934999090
• Mol file: 131436-78-7.mol

Synonyms:ETHYL 4-HYDROXY-5-OXO-1-(2-THIENYLMETHYL)-2,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLATE

Chemical Property of ETHYL 4-HYDROXY-5-OXO-1-(2-THIENYLMETHYL)-2,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 2.14E-10mmHg at 25°C
• Melting Point: 98-100°C
• Refractive Index: 1.64
• Boiling Point: 489.5°Cat760mmHg
• Flash Point: 249.8°C
• PSA: 95.08000
• Density: 1.449g/cm³
• LogP: 1.40340

Purity/Quality:

98%Min ^*data from raw suppliers

Ethyl4-Hydroxy-5-oxo-1-(2-thienylmethyl)-2,5-dihydro-1H-pyrrole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-HYDROXY-5-OXO-1-(2-THIENYLMETHYL)-2,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLATE

There total 2 articles about ETHYL 4-HYDROXY-5-OXO-1-(2-THIENYLMETHYL)-2,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

ethyl 3-<(2-thienylmethyl)amino>propionate (131436-68-5) + oxalic acid diethyl ester (95-92-1) → 4-Hydroxy-5-oxo-1-thiophen-2-ylmethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester (131436-78-7)

Guidance literature:

With sodium ethanolate; for 1h; Heating;

DOI:10.1021/jm00107a020

Reference yield:

2-Aminomethylthiophene (27757-85-3) → 4-Hydroxy-5-oxo-1-thiophen-2-ylmethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester (131436-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / ethanol

2: 33 percent / NaOEt / 1 h / Heating

With sodium ethanolate; In ethanol;

DOI:10.1021/jm00107a020

upstream raw materials:

ethyl 3-<(2-thienylmethyl)amino>propionate

oxalic acid diethyl ester

2-Aminomethylthiophene