131436-68-5Relevant articles and documents
Synthesis and structure-activity relationship study of arylsulfonamides as novel potent H5N1 inhibitors
Yu, Yongshi,Tang, Qi,Xu, Zhichao,Li, Siliang,Jin, Mengyu,Zhao, Zixuan,Dong, Chune,Wu, Shuwen,Zhou, Hai-Bing
, p. 206 - 216 (2018)
H5N1 virus, one subtype of highly pathogenic influenza A virus in human infection, has recently received attention due to its unpredictable and high mortality. In this study, a series of arylsulfonamide derivatives were identified as improved H5N1 inhibitors for the influenza treatment by systematic structure-activity relationship investigation. Among them, the most potent H5N1 inhibitor 3h exhibited excellent antiviral activity against H5N1 virus with EC50 value of 0.006 μM and selectivity index 33543.3. Moreover, the molecular docking of 3h with M2 proton channel protein provides practical way for understanding the inhibition of H5N1 with this kind of compounds.
HETEROARYL DERIVATIVES
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Page/Page column 26, (2010/01/29)
The present invention relates to a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof. In the formula [1], either of X and Y is CH and the other is oxygen or sulfur; R is hydrogen, etc.; Z is hydrogen, etc.; Ar
A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners
Mylari,Beyer,Siegel
, p. 1011 - 1018 (2007/10/02)
Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate (1, EBPC) is a potent and specific inhibitor of aldose reductase. It was >4000X more potent in its inhibition of rat lens aldose reductase than the closely related rat or pig kidney aldehyde reductas
