3,4-Dihydro-3-[(4-morpholinyl)methyl]-2H-1,4-benzoxazine

Base Information

Chemical Name:3,4-Dihydro-3-[(4-morpholinyl)methyl]-2H-1,4-benzoxazine
CAS No.:131513-35-4
Molecular Formula:C13H18N2O2
Molecular Weight:234.298
Hs Code.:2934999090
DSSTox Substance ID:DTXSID20349509
ChEMBL ID:CHEMBL1338290
Mol file:131513-35-4.mol

Synonyms:131513-35-4;3,4-Dihydro-3-[(4-morpholinyl)methyl]-2H-1,4-benzoxazine;3-(morpholin-4-ylmethyl)-3,4-dihydro-2H-1,4-benzoxazine;1,4-DIHYDRO-3-(4-MORPHOLINYLMETHYL)-2H-BENZO[B][1,4]OXAZINE;3-(Morpholinomethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine;3-[(Morpholin-4-yl)methyl]-3,4-dihydro-2H-1,4-benzoxazine;MLS000035126;TimTec1_008068;Oprea1_052418;Oprea1_350716;SCHEMBL9701340;CHEMBL1338290;3-Morpholin-4-ylmethyl-3,4-dihydro-2H-benzo[1,4]oxazine;DTXSID20349509;PBDBHLSLPCKGRV-UHFFFAOYSA-N;HMS1556O16;HMS2277G24;AKOS000638928;AKOS022180850;IDI1_033722;AC-16414;SMR000009490;FT-0643151;(+)-3-(4-morpholinylmethyl)-3,4-dihydro-2H-1,4-benzoxazine;(-)-3-(4-morpholinylmethyl)-3,4-dihydro-2H-1,4-benzoxazine;racemic 3-(4-morpholinylmethyl)-3,4-dihydro-2H-1,4-benzoxazine

Suppliers and Price of 3,4-Dihydro-3-[(4-morpholinyl)methyl]-2H-1,4-benzoxazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1,4-DIHYDRO-3-(4-MORPHOLINYLMETHYL)-2H-1,4-BENZOXAZINE 95.00%
5MG
$ 501.78

AHH
3,4-Dihydro-3-[(4-morpholinyl)methyl]-2H-1,4benzoxazine 98%
1g
$ 446.00

Total 10 raw suppliers

Chemical Property of 3,4-Dihydro-3-[(4-morpholinyl)methyl]-2H-1,4-benzoxazine

Chemical Property:

Vapor Pressure:5.85E-06mmHg at 25°C
Refractive Index:1.546
Boiling Point:379.5°C at 760 mmHg
Flash Point:183.3°C
PSA：33.73000
Density:1.139g/cm³
LogP:1.26760
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:234.136827821
Heavy Atom Count:17
Complexity:244

Purity/Quality:

98% ^*data from raw suppliers

1,4-DIHYDRO-3-(4-MORPHOLINYLMETHYL)-2H-1,4-BENZOXAZINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1CC2COC3=CC=CC=C3N2

Technology Process of 3,4-Dihydro-3-[(4-morpholinyl)methyl]-2H-1,4-benzoxazine

There total 3 articles about 3,4-Dihydro-3-[(4-morpholinyl)methyl]-2H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 131513-33-2
3-(4-morpholinyl)-1-(2-nitrophenoxy)-2-propanone

: 131513-35-4
3,4-dihydro-3-<(4-morpholinyl)methyl>-2H-1,4-benzoxazine

Guidance literature:: With hydrogen; Ra-Ni; In ethyl acetate; for 6h; under 2327.2 Torr;
DOI:10.1021/jm00079a016

Reference yield:

: 131513-32-1
1-Morpholin-4-yl-3-(2-nitro-phenoxy)-propan-2-ol

: 131513-35-4
3,4-dihydro-3-<(4-morpholinyl)methyl>-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DMSO, trifluoroacetic anhydride, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) RT, 30 min

2: 96 percent / H₂ / Ra-Ni / ethyl acetate / 6 h / 2327.2 Torr

With hydrogen; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; Ra-Ni; In ethyl acetate;
DOI:10.1021/jm00079a016