3-(4-morpholinylmethyl)-5-methyl-6-(4-methoxybenzoyl)-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine

Base Information

Chemical Name:3-(4-morpholinylmethyl)-5-methyl-6-(4-methoxybenzoyl)-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine
CAS No.:131513-17-2
Molecular Formula:C₂₄H₂₆N₂O₄
Molecular Weight:406.481
Hs Code.:

Synonyms:3-(4-morpholinylmethyl)-5-methyl-6-(4-methoxybenzoyl)-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine

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Chemical Property of 3-(4-morpholinylmethyl)-5-methyl-6-(4-methoxybenzoyl)-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine

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Technology Process of 3-(4-morpholinylmethyl)-5-methyl-6-(4-methoxybenzoyl)-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine

There total 9 articles about 3-(4-morpholinylmethyl)-5-methyl-6-(4-methoxybenzoyl)-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144-55-8
sodium hydrogencarbonate

: 100-07-2
4-methoxy-benzoyl chloride

: 131513-58-1,131543-27-6,137794-93-5
(+)-3-(morpholin-4-ylmethyl)-5-methyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine

: 131513-17-2
3-(4-morpholinylmethyl)-5-methyl-6-(4-methoxybenzoyl)-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine

Guidance literature:: aluminium trichloride; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane;

Reference yield:

: 4023-80-7
1-(4-methoxyphenyl)butan-1,3-dione

: 137794-91-3
1-amino-3,4-dihydro-3-<(4-morpholinyl)methyl>-2H-1,4-benzoxazine

: 100-06-1
1-(4-methoxyphenyl)ethanone

: (+)-3-(4-morpholinylmethyl)-5-methyl-6-(4-methoxybenzovl)-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine

: 131513-17-2
3-(4-morpholinylmethyl)-5-methyl-6-(4-methoxybenzoyl)-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine

Guidance literature:: ethanol; pyridinium paratoluene sulfonic acid; In diethyl ether; acetic acid; ethyl acetate; toluene;

Reference yield:

: 131513-32-1
1-Morpholin-4-yl-3-(2-nitro-phenoxy)-propan-2-ol

: 131513-17-2
3-(4-morpholinylmethyl)-5-methyl-6-(4-methoxybenzoyl)-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) DMSO, trifluoroacetic anhydride, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) RT, 30 min

2: 96 percent / H₂ / Ra-Ni / ethyl acetate / 6 h / 2327.2 Torr

3: NaNO₂, 2 N aq. HCl / H₂O / 1 h / 0 °C

4: LiAlH₄ / tetrahydrofuran / 1 h / Heating

5: 33 percent / acetic acid / 1 h / Heating

6: 87 percent / Raney-Ni, EtOH / 1 h / Heating

7: 1.) AlCl₃ / 1.) CH₂Cl₂, 1 h, 2.) CH₂Cl₂, reflux, 20 min

With hydrogenchloride; lithium aluminium tetrahydride; aluminium trichloride; ethanol; hydrogen; nickel; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; sodium nitrite; Ra-Ni; In tetrahydrofuran; water; acetic acid; ethyl acetate;
DOI:10.1021/jm00079a016