Piperazine, 2-(trifluoromethyl)- (9CI)

Base Information

• Chemical Name: Piperazine, 2-(trifluoromethyl)- (9CI)
• CAS No.: 131922-05-9
• Molecular Formula: C5H9 F3 N2
• Molecular Weight: 154.135
• Hs Code.: 2933599590
• Mol file: 131922-05-9.mol

Synonyms:2-(Trifluoromethyl)piperazine

Chemical Property of Piperazine, 2-(trifluoromethyl)- (9CI)

Chemical Property:

• Vapor Pressure: 4.94mmHg at 25°C
• Melting Point: 94-97℃
• Refractive Index: 1.372
• Boiling Point: 145.1°C at 760 mmHg
• PKA: 7.75±0.40(Predicted)
• Flash Point: 41.5°C
• PSA: 24.06000
• Density: 1.171g/cm³
• LogP: 0.76770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Trifluoromethyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,N
• Hazard Codes: C,N
• Statements: 34-50/53
• Safety Statements: 6-26-36/37/39-45-60-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperazine, 2-(trifluoromethyl)- (9CI)

There total 4 articles about Piperazine, 2-(trifluoromethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-benzyl-3-(trifluoromethyl)piperazine (167566-34-9) → (+/-)-2-(trifluoromethyl)piperazine (131922-05-9)

Guidance literature:

With cyclohexene; palladium on activated charcoal; Heating;

DOI:10.1002/recl.19951140305

Reference yield:

2-(trifluoromethyl)pyrazine (61655-67-2) → (+/-)-2-(trifluoromethyl)piperazine (131922-05-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; ethyl acetate; at 60 ℃; for 14h;

Reference yield:

3-bromo-1,1,1-trifluoroacetone (431-35-6) + N,N'-Dibenzylethylenediamine (140-28-3,87170-83-0) → (+/-)-2-(trifluoromethyl)piperazine (131922-05-9)

Guidance literature:

With sodium borohydrid; dimethyl sulfoxide; palladium; In ethanol; water;

upstream raw materials:

1-benzyl-3-(trifluoromethyl)piperazine

3-bromo-1,1,1-trifluoroacetone

N,N'-Dibenzylethylenediamine

2-(trifluoromethyl)pyrazine

Refernces

• 1、 -. "DOSAGE FORM COMPOSITIONS COMPRISING AN INHIBITOR OF BTK AND MUTANTS THEREOF". Page/Page column 22; 41. . Retrieved 2022/02/28.
• 2、 -. "NOVEL BENZOFURAN DERIVATIVES, WHICH CAN BE USED IN PROPHYLAXIS OR TREATMENT OF 5-HT6 RECEPTOR-RELATED DISORDER". Page/Page column 121. . Retrieved 2010/02/12.