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4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one,5-amino-5,6-dihydro-,(R)-(9CI)

Base Information Edit
  • Chemical Name:4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one,5-amino-5,6-dihydro-,(R)-(9CI)
  • CAS No.:132875-37-7
  • Molecular Formula:C10H11N3O
  • Molecular Weight:189.217
  • Hs Code.:
  • Mol file:132875-37-7.mol
4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one,5-amino-5,6-dihydro-,(R)-(9CI)

Synonyms:4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one,5-amino-5,6-dihydro-,(R)-(9CI)

Suppliers and Price of 4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one,5-amino-5,6-dihydro-,(R)-(9CI)
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
Total 1 raw suppliers
Chemical Property of 4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one,5-amino-5,6-dihydro-,(R)-(9CI) Edit
Chemical Property:
  • PSA:63.81000 
  • LogP:0.91330 
Purity/Quality:

98% *data from raw suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
Technology Process of 4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one,5-amino-5,6-dihydro-,(R)-(9CI)

There total 19 articles about 4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one,5-amino-5,6-dihydro-,(R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; for 20h; under 2585.81 Torr;
DOI:10.1021/acs.jmedchem.5b01612
Guidance literature:
Multi-step reaction with 9 steps
1: sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; dichloromethane / 24 h / 20 °C
2: bis-[(trifluoroacetoxy)iodo]benzene; trifluoroacetic acid / dichloromethane / 1.17 h / 0 °C
3: hydrogen; palladium 10% on activated carbon / ethanol / 2585.81 Torr
4: dimethyl sulfide borane / tetrahydrofuran / 120 h / 0 - 20 °C / Reflux
5: toluene / -40 °C
6: triethylamine / tetrahydrofuran / 1 h / 0 °C
7: triethylamine / tetrahydrofuran / 48 h / 20 °C
8: bis-[(trifluoroacetoxy)iodo]benzene / chloroform / 6 h / -5 - 20 °C
9: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 20 h / 2585.81 Torr
With palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; hydrogen; dimethyl sulfide borane; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene;
DOI:10.1021/acs.jmedchem.5b01612
Guidance literature:
With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 3.5h;
DOI:10.1002/ejoc.201200344
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