Technology Process of 4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one,5-amino-5,6-dihydro-,(R)-(9CI)
There total 19 articles about 4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one,5-amino-5,6-dihydro-,(R)-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; dichloromethane / 24 h / 20 °C
2: bis-[(trifluoroacetoxy)iodo]benzene; trifluoroacetic acid / dichloromethane / 1.17 h / 0 °C
3: hydrogen; palladium 10% on activated carbon / ethanol / 2585.81 Torr
4: dimethyl sulfide borane / tetrahydrofuran / 120 h / 0 - 20 °C / Reflux
5: toluene / -40 °C
6: triethylamine / tetrahydrofuran / 1 h / 0 °C
7: triethylamine / tetrahydrofuran / 48 h / 20 °C
8: bis-[(trifluoroacetoxy)iodo]benzene / chloroform / 6 h / -5 - 20 °C
9: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 20 h / 2585.81 Torr
With
palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; hydrogen; dimethyl sulfide borane; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene;
DOI:10.1021/acs.jmedchem.5b01612
- Guidance literature:
-
With
potassium tert-butylate;
In
tetrahydrofuran;
at 20 ℃;
for 3.5h;
DOI:10.1002/ejoc.201200344