Urea,N-(3-chlorophenyl)-N'-2-thiazolyl-

Base Information

• Chemical Name: Urea,N-(3-chlorophenyl)-N'-2-thiazolyl-
• CAS No.: 161527-66-8
• Molecular Formula: C10H8 Cl N3 O S
• Molecular Weight: 253.712
• Hs Code.: 2934100090
• Mol file: 161527-66-8.mol

Synonyms:NSC 321792

Chemical Property of Urea,N-(3-chlorophenyl)-N'-2-thiazolyl-

Chemical Property:

• PSA: 85.75000
• Density: 1.542g/cm³
• LogP: 3.52710

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(3-CHLOROPHENYL)-N'-(1,3-THIAZOL-2-YL)UREA AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Urea,N-(3-chlorophenyl)-N'-2-thiazolyl-

There total 2 articles about Urea,N-(3-chlorophenyl)-N'-2-thiazolyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-thiazolylamine (96-50-4) + m-chlorophenyl isocyanate (2909-38-8) → N-(3-chlorophenyl)-N’-2-thiazolylurea (161527-66-8)

Guidance literature:

In acetonitrile; at 20 ℃;

DOI:10.2174/1573406411208061057

Reference yield: 51.0%

2-thiazolylamine (96-50-4) + carbon monoxide (201230-82-2) + 3-Nitrochlorobenzene (121-73-3) → N-(3-chlorophenyl)-N’-2-thiazolylurea (161527-66-8)

Guidance literature:

With selenium; triethylamine; In toluene; at 130 ℃; for 8h; under 22502.3 Torr; Autoclave; Sealed tube;

DOI:10.1016/j.tetlet.2016.10.046

upstream raw materials:

2-thiazolylamine

m-chlorophenyl isocyanate

carbon monoxide

3-Nitrochlorobenzene

Refernces

• 1、 Azam, Faizul,Shrivastava, Anil Kumar,Mohan, Govind,Prasad, Medapati Vijaya Vara,Thangavel, Neelaveni. "Structure-based design, synthesis and molecular modeling studies of thiazolyl urea derivatives as novel anti-parkinsonian agents". . p. 1057 - 1068,12. Retrieved 2012/12/12.