2-Morpholinecarboxylicacid,ethylester(9CI)

Base Information

• Chemical Name: 2-Morpholinecarboxylicacid,ethylester(9CI)
• CAS No.: 135782-25-1
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.185
• Hs Code.: 2934999090
• Mol file: 135782-25-1.mol

Synonyms:ethyl morpholine-2-carboxylate;

Chemical Property of 2-Morpholinecarboxylicacid,ethylester(9CI)

Chemical Property:

• Vapor Pressure: 0.107mmHg at 25°C
• Refractive Index: 1.441
• Boiling Point: 221.404 °C
• PKA: 7.84±0.40(Predicted)
• Flash Point: 87.702 °C
• PSA: 47.56000
• Density: 1.078 g/cm³
• LogP: -0.13330
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

2-Morpholinecarboxylic Acid Ethyl Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Morpholinecarboxylicacid,ethylester(9CI)

There total 5 articles about 2-Morpholinecarboxylicacid,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl 4-benzylmorpholine-2-carboxylate (135072-32-1,107904-08-5) → 2-morpholinecarboxylic acid ethyl ester (135782-25-1)

Guidance literature:

With hydrogen; trifluoroacetic acid; palladium on activated charcoal;

DOI:10.1021/jm00058a004

Reference yield: 80.0%

ethanol (64-17-5) + morpholine-2-carbonitrile (135782-24-0,1359658-57-3,1262484-62-7) → 2-morpholinecarboxylic acid ethyl ester (135782-25-1)

Guidance literature:

With sulfuric acid;

DOI:10.1016/S0040-4039(00)79702-4

Reference yield:

3-(benzyl(2-hydroxyethyl)amino)-2-chloro-propanenitrile (1030837-46-7) → 2-morpholinecarboxylic acid ethyl ester (135782-25-1)

Guidance literature:

Multi-step reaction with 3 steps

1: KOBu-t / 1,2-dimethoxy-ethane / 1.) 0 deg C, 2 h, 2.) reflux, 1 h

2: 79 percent / concd. H₂SO₄ / 48 h / Heating

3: 87 percent / trifluoroacetic acid, hydrogen / Pd/C

With sulfuric acid; potassium tert-butylate; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In 1,2-dimethoxyethane;

DOI:10.1021/jm00058a004

upstream raw materials:

ethanol

morpholine-2-carbonitrile

ethyl 4-benzylmorpholine-2-carboxylate

4-benzyl-2-cyanomorpholine

Downstream raw materials:

4-{2-methoxy-6-[2-(4-trifluoromethoxyphenyl)ethylamino]pyrimidin-4-yl}morpholine-2-carboxylic acid ethyl ester

Refernces

• 1、 -. "Oligopetides with cyclic proline-analogous amino acids". . . Retrieved 2008/06/13.