N-(4-fluorophenyl)thiophene-2-carboxamide

Base Information

Chemical Name:N-(4-fluorophenyl)thiophene-2-carboxamide
CAS No.:136340-91-5
Molecular Formula:C11H8FNOS
Molecular Weight:221.255
Hs Code.:2934999090
DSSTox Substance ID:DTXSID401272200
Nikkaji Number:J1.828.896F
ChEMBL ID:CHEMBL1531343
Mol file:136340-91-5.mol

Synonyms:N-(4-fluorophenyl)thiophene-2-carboxamide;136340-91-5;N-(4-Fluorophenyl)-2-thiophenecarboxamide;2-THIOPHENECARBOXAMIDE,N-(4-FLUOROPHENYL)-;Thiophene-2-carboxamide, N-(4-fluorophenyl)-;SR-01000392624-3;cid_531923;CHEMBL1531343;BDBM41629;DTXSID401272200;STK125440;AKOS001142333;CCG-200533;SR-01000392624;SR-01000392624-1;Z27805988

Suppliers and Price of N-(4-fluorophenyl)thiophene-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Aronis compounds
N-(4-fluorophenyl)-2-thiophenecarboxamide
20mg
$ 30.00

American Custom Chemicals Corporation
2-THIOPHENECARBOXAMIDE,N-(4-FLUOROPHENYL)- 95.00%
5MG
$ 495.42

Total 1 raw suppliers

Chemical Property of N-(4-fluorophenyl)thiophene-2-carboxamide

Chemical Property:

PSA：60.83000
LogP:3.52350
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:221.03106321
Heavy Atom Count:15
Complexity:229

Purity/Quality:

99.0%min ^*data from raw suppliers

N-(4-fluorophenyl)-2-thiophenecarboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CSC(=C1)C(=O)NC2=CC=C(C=C2)F

Technology Process of N-(4-fluorophenyl)thiophene-2-carboxamide

There total 4 articles about N-(4-fluorophenyl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 5813-89-8
2-thiophenylcarboxamide

: 352-34-1
4-fluoro-1-iodobenzene

: 136340-91-5
N-(4-fluorophenyl)-2-thiophenecarboxamide

Guidance literature:: With iron(III) chloride; potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 135 ℃; for 24h; Inert atmosphere;
DOI:10.1002/chem.200800293

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: 371-40-4
4-fluoroaniline

: 136340-91-5
N-(4-fluorophenyl)-2-thiophenecarboxamide

Guidance literature:: 2-thiophenylcarboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

4-fluoroaniline; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.molstruc.2018.07.114

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: 136340-91-5
N-(4-fluorophenyl)-2-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / Heating

2: toluene

With thionyl chloride; In toluene;