Epzicom

Base Information

Chemical Name:Epzicom
CAS No.:136470-79-6
Molecular Formula:C₁₄H₁₈N₆O
Molecular Weight:286.337
Hs Code.:
UNII:X9A7099R51
DSSTox Substance ID:DTXSID20332855
Nikkaji Number:J1.303.600D
Wikidata:Q27293722
Mol file:136470-79-6.mol

Synonyms:((1R,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-cyclopent-2-enyl)methanol;((1R,4S)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enyl)methanol;(+)-abacavir;(+)-abacavir sulfate;(+-)-abacavir sulfate;(-)-cis-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol;(1R,4R)-abacavir;(1R,4S)-abacavir sulfate;(1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol;(1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol succinate (1:1) (salt);1592U89;2-cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1R,4S)-, sulfate (2:1);2-cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S,4R)-, rel-, sulfate (2:1);2-cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, hydrochloride, hydrate (1:1:1), (1S,4R)-;abacavir;abacavir enantiomer;abacavir hydrochloride monohydrate;abacavir succinate;abacavir sulfate;abacavir sulfate racemic;abacavir sulfate, (+)-;abacavir sulfate, (+-)-;abacavir sulfate, (1R,4S)-;abacavir sulphate;abacavir, (+)-;abacavir, (1R,4S)-;abacavir, trans-;abacavir, trans-, (+-)-;Abamune;avacavir;DRG 0257;DRG-0257;DRG0257;trans-abacavir;trans-abacavir R,R-;Ziagen;abacavir - lamivudine;abacavir and lamivudine drug combination;abacavir sulfate and lamivudine;abacavir sulfate-lamivudine combination;abacavir, lamivudine drug combination;abacavir-lamivudine combination;Epzicom;Kivexa

Suppliers and Price of Epzicom

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ent-Abacavir
5mg
$ 496.00

TRC
ent-Abacavir
2.5mg
$ 205.00

Biosynth Carbosynth
ent-abacavir
50 mg
$ 1911.00

Biosynth Carbosynth
ent-abacavir
25 mg
$ 1051.50

Biosynth Carbosynth
ent-abacavir
10 mg
$ 578.20

Biosynth Carbosynth
ent-abacavir
2 mg
$ 174.90

Biosynth Carbosynth
ent-abacavir
5 mg
$ 318.00

AK Scientific
Epzicom
2mg
$ 286.00

Total 11 raw suppliers

Chemical Property of Epzicom

Chemical Property:

Boiling Point:636.0±65.0 °C(Predicted)
PKA:14.86±0.10(Predicted)
PSA：102.61000
Density:1.70±0.1 g/cm3(Predicted)
LogP:1.09540
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:286.15420922
Heavy Atom Count:21
Complexity:414

Purity/Quality:

99%, ^*data from raw suppliers

ent-Abacavir ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO
Isomeric SMILES:C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)[C@H]4C[C@H](C=C4)CO
Recent ClinicalTrials:Relative Bioavailability Study of a Fixed-dose Combination Dolutegravir/Abacavir/Lamivudine Dispersible Tablet
Uses The enatiomer of the nucleoside reverse transcriptase inhibitor (NRTI) Abacavir (A105000) with similar antiviral properties.

Technology Process of Epzicom

There total 71 articles about Epzicom which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 136522-33-3,172721-00-5
(1S,4R)-4-[2-amino-6-chloro-9H-purin-9-yl]-2-cyclopentene-1-methanol

: 765-30-0
Cyclopropylamine

: 136470-78-5,128131-83-9,136470-79-6
abacavir

Guidance literature:: In ethanol; at 70 ℃;
DOI:10.1002/cmdc.201800361

Reference yield: 90.0%

: 765-30-0
Cyclopropylamine

: 172015-79-1
((1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol hydrochloride

: 136470-78-5,128131-83-9,136470-79-6
abacavir

Guidance literature:: In methanol; at 70 ℃; for 12h;
DOI:10.1080/15257770008033011

Reference yield: 90.0%

: 136470-88-7
(-)-N-{6-(cyclopropylamino)-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-enyl]-9H-purin-2-yl}isobutyramide

: 136470-78-5,128131-83-9,136470-79-6
abacavir

Guidance literature:: (-)-N-{6-(cyclopropylamino)-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-enyl]-9H-purin-2-yl}isobutyramide; With isopropyl alcohol; sodium hydroxide; for 1h; Reflux;

With hydrogenchloride; In water; isopropyl alcohol; at 20 - 25 ℃; pH=7.0 - 7.5; Product distribution / selectivity;