6-Chloro-2-methylpyrimidine-4-carbonyl chloride

Base Information

Chemical Name:6-Chloro-2-methylpyrimidine-4-carbonyl chloride
CAS No.:136518-02-0
Molecular Formula:C6H4Cl2N2O
Molecular Weight:191.01
Hs Code.:
DSSTox Substance ID:DTXSID10597431
Wikidata:Q82492972
Mol file:136518-02-0.mol

Synonyms:6-chloro-2-methylpyrimidine-4-carbonyl chloride;136518-02-0;4-Pyrimidinecarbonylchloride,6-chloro-2-methyl-(9CI);SCHEMBL985142;DTXSID10597431;ARSCUXURTSKMQU-UHFFFAOYSA-N;DB-359394;6-chloro-2-methylpyrimidine-4-carbonylchloride;6-Chloro-2-methyl-4-pyrimidinecarbonyl chloride;6-chloro-2-methyl-pyrimidine-4-carboxylic acid chloride

Suppliers and Price of 6-Chloro-2-methylpyrimidine-4-carbonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 6-Chloro-2-methylpyrimidine-4-carbonyl chloride

Chemical Property:

PSA：42.85000
LogP:1.81740
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:189.9700681
Heavy Atom Count:11
Complexity:165

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC(=CC(=N1)Cl)C(=O)Cl

Technology Process of 6-Chloro-2-methylpyrimidine-4-carbonyl chloride

There total 2 articles about 6-Chloro-2-methylpyrimidine-4-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 34415-10-6
6-hydroxy-2-methylpyrimidine-4-carboxylic acid

: 136518-02-0
6-chloro-2-methylpyrimidine-4-carbonyl chloride

Guidance literature:: With trichlorophosphate; for 1h; Heating / reflux;

Reference yield:

: 6-hydroxy-2-methylpyrimidine-4-carboxylic acid hydrate

: 10026-13-8,874483-75-7
phosphorus pentachloride

: 136518-02-0
6-chloro-2-methylpyrimidine-4-carbonyl chloride

Guidance literature:: In water; trichlorophosphate;

Reference yield:

: 136518-02-0
6-chloro-2-methylpyrimidine-4-carbonyl chloride

: 2-(6-chloro-2-methylpyrimidin-4-yl)-5-(1-(4-(trifluoromethyl)phenyl)ethyl)oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane / 12 h / 0 - 20 °C

2: trichlorophosphate / toluene / 24 h / Reflux

With sodium hydrogencarbonate; trichlorophosphate; In dichloromethane; toluene;