(3S,4S)-3,4-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]pyrrolidine

Base Information

Chemical Name:(3S,4S)-3,4-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]pyrrolidine
CAS No.:138228-47-4
Molecular Formula:C16H37NO2Si2
Molecular Weight:331.64
Hs Code.:
Nikkaji Number:J1.733.407G
Mol file:138228-47-4.mol

Synonyms:138228-47-4;(3S,4S)-3,4-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]pyrrolidine;Pyrrolidine, 3,4-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3S,4S)-;(3S,4S)-3,4-Bis((tert-butyldimethylsilyl)oxy)pyrrolidine;tert-butyl-[(3S,4S)-4-[tert-butyl(dimethyl)silyl]oxypyrrolidin-3-yl]oxy-dimethylsilane;SCHEMBL956313;KGWDAGKEVSFIBY-KBPBESRZSA-N;MFCD07357278;BS-42501;(3S,4S)-3,4-bis[(tert-butyl-dimethylsilyl)oxy]pyrrolidine;(3S,4S)-3,4-BIS{[TERT-BUTYL(DIMETHYL)SILYL]OXY}PYRROLIDINE

Suppliers and Price of (3S,4S)-3,4-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(3S,4S)-3,4-BIS[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]PYRROLIDINE 95.00%
100MG
$ 399.00

Absolute Chiral
(3S,4S)-3,4-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]pyrrolidine 95%
250 mg
$ 598.00

Abosyn
(3S,4S)-3,4-bis((tert-butyldimethylsilyl)oxy)pyrrolidine 95%-98%
1g
$ 190.00

Total 2 raw suppliers

Chemical Property of (3S,4S)-3,4-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]pyrrolidine

Chemical Property:

PSA：30.49000
LogP:4.69920
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:331.23628249
Heavy Atom Count:21
Complexity:322

Purity/Quality:

97% ^*data from raw suppliers

(3S,4S)-3,4-BIS[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]PYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OC1CNCC1O[Si](C)(C)C(C)(C)C
Isomeric SMILES:CC(C)(C)[Si](C)(C)O[C@H]1CNC[C@@H]1O[Si](C)(C)C(C)(C)C

Technology Process of (3S,4S)-3,4-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]pyrrolidine

There total 3 articles about (3S,4S)-3,4-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 138228-45-2
(3S,4S)-1-benzyl-3,4-bis{[(tert-butyl)dimethylsilyl]oxy}pyrrolidine

: 138228-47-4
(3S,4S)-3,4-bis<(tert-butyl)dimethylsilyloxy>pyrrolidine

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 20h; under 760 Torr;
DOI:10.1016/0957-4166(96)00200-5

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 138228-47-4
(3S,4S)-3,4-bis<(tert-butyl)dimethylsilyloxy>pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / imidazole / dimethylformamide / 1 h / 60 °C

2: 100 percent / H₂ / 20percent Pd(OH)2 / methanol / 20 h / 20 °C / 760 Torr

With 1H-imidazole; hydrogen; palladium dihydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/0957-4166(96)00200-5

Reference yield:

: 136137-86-5
(3R,4R)-3,4-Bis<(tert-butyldimethylsilyl)oxy>-1-benzyl-2,5-pyrrolidinedione

: 138228-47-4
(3S,4S)-3,4-bis<(tert-butyl)dimethylsilyloxy>pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: borane-THF / tetrahydrofuran / 0 °C / Reflux; Inert atmosphere

1.2: 21 h / Inert atmosphere; Reflux

2.1: 20% palladium hydroxide-activated charcoal; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

With borane-THF; 20% palladium hydroxide-activated charcoal; hydrogen; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetlet.2014.02.132