4-Pyrimidinecarboxylic acid, 6-methyl- (9CI)

Base Information

• Chemical Name: 4-Pyrimidinecarboxylic acid, 6-methyl- (9CI)
• CAS No.: 138538-42-8
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.12404
• Hs Code.: 2933599090
• Mol file: 138538-42-8.mol

Synonyms:4-Pyrimidinecarboxylic acid, 6-methyl- (9CI)

Chemical Property of 4-Pyrimidinecarboxylic acid, 6-methyl- (9CI)

Chemical Property:

• PSA: 63.08000
• LogP: 0.48320
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-Methylpyrimidine-4-CarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyrimidinecarboxylic acid, 6-methyl- (9CI)

There total 4 articles about 4-Pyrimidinecarboxylic acid, 6-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl 6-methylpyrimidine-4-carboxylate (148149-29-5) → 6-methylpyrimidine-4-carboxylic acid (138538-42-8)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2019.05.005

Reference yield:

4,6-dimethylpyrimidine (1558-17-4) → 6-methylpyrimidine-4-carboxylic acid (138538-42-8)

Guidance literature:

With potassium permanganate; water;

Reference yield:

ethyl 4-methoxy-2-oxo-3-pentenoate → 6-methylpyrimidine-4-carboxylic acid (138538-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 2 h / 70 °C / Reflux

2: potassium hydroxide / ethanol / 2 h / 20 °C

With potassium carbonate; potassium hydroxide; In ethanol; acetonitrile;

DOI:10.1016/j.tet.2019.05.005

upstream raw materials:

4,6-dimethylpyrimidine

2-chloro-4,6-dimethylpyrimidine

ethyl 6-methylpyrimidine-4-carboxylate

Downstream raw materials:

6-Methylpyrimidin-4-carbonsaeuremethylester

6-methyl-4-(1-oxopropyl)pyrimidine

Refernces

• 1、 -. "METALLOPROTEASE INHIBITORS". Page/Page column 67. . Retrieved 2008/06/13.