(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

Base Information

Chemical Name:(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid
CAS No.:138775-02-7
Molecular Formula:C18H24N2O6
Molecular Weight:364.398
Hs Code.:2933599090
European Community (EC) Number:675-826-3
DSSTox Substance ID:DTXSID00426685
Wikidata:Q72500084
Mol file:138775-02-7.mol

Synonyms:138775-02-7;(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid;(R)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid;(2R)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-phenylmethoxycarbonylpiperazine-2-carboxylic acid;(R)-1-N-BOC-4-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID;(2r)-piperazine-1,2,4-tricarboxylic acid 4-benzyl ester 1-tert-butyl ester;(2R)-4-[(BENZYLOXY)CARBONYL]-1-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID;MFCD02179112;1,2,4-PIPERAZINETRICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) 4-(PHENYLMETHYL) ESTER, (2R)-;SCHEMBL3766378;DTXSID00426685;CS-D1330;AKOS015924699;AKOS015994875;DS-0929;(2r)-4-[(benzyloxy)carbonyl]-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid;(R)-4-((Benzyloxy)carbonyl)-1-BOC-piperazine-2-carboxylic acid;(2R)-4-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-piperazinecarboxylic acid;(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)-piperazine-2-carboxylic acid;(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylicacid;(r)-4-(benzyloxycarbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid;(R)-4-(benzyloxycarbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

Suppliers and Price of (R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)-piperazine-2-carboxylicacid >95%
1g
$ 630.00

Crysdot
(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylicacid 95+%
10g
$ 683.00

Crysdot
(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylicacid 95+%
5g
$ 437.00

Chemenu
(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)-piperazine-2-carboxylicacid 95%+
250mg
$ 56.00

American Custom Chemicals Corporation
(R)-N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID 95.00%
25G
$ 3343.73

American Custom Chemicals Corporation
(R)-N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID 95.00%
5G
$ 1553.48

American Custom Chemicals Corporation
(R)-N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID 95.00%
1G
$ 310.80

Alichem
(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylicacid
1g
$ 172.48

Alichem
(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylicacid
5g
$ 542.81

Alichem
(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylicacid
10g
$ 774.20

Total 31 raw suppliers

Chemical Property of (R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

Chemical Property:

Vapor Pressure:1.36E-11mmHg at 25°C
Refractive Index:1.555
Boiling Point:518.9°Cat760mmHg
Flash Point:267.6°C
PSA：96.38000
Density:1.272g/cm³
LogP:2.20490
Storage Temp.:2-8°C
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:364.16343649
Heavy Atom Count:26
Complexity:524

Purity/Quality:

99%, ^*data from raw suppliers

(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)-piperazine-2-carboxylicacid >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCN(CC1C(=O)O)C(=O)OCC2=CC=CC=C2
Isomeric SMILES:CC(C)(C)OC(=O)N1CCN(C[C@@H]1C(=O)O)C(=O)OCC2=CC=CC=C2

Technology Process of (R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

There total 4 articles about (R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: C₅H₁₀N₂O₂*2C₉H₁₄O₄S

: 24424-99-5
di-tert-butyl dicarbonate

: 501-53-1,94274-21-2
benzyl chloroformate

: 256446-66-9
(R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid

: 138775-02-7
(2R)-4-[(benzyloxy)carbonyl]-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid

Guidance literature:: C₅H₁₀N₂O₂*2C₉H₁₄O₄S; benzyl chloroformate; With sodium hydroxide; In 1,4-dioxane; at 0 - 5 ℃; for 1.5 - 1.75h; pH=10.5 - 11.0;

With hydrogenchloride; water; pH=4.0;

di-tert-butyl dicarbonate; With hydrogenchloride; sodium hydroxide; more than 3 stages;

Reference yield:

: ethyl (2R)-4-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-piperazinecarboxylate

: 138775-02-7
(2R)-4-[(benzyloxy)carbonyl]-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 276695-09-1
(R)-4-carbobenzyloxypiperazine-2-carboxylic acid

: 138775-02-7
(2R)-4-[(benzyloxy)carbonyl]-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid

Guidance literature:: (R)-4-carbobenzyloxypiperazine-2-carboxylic acid; With ethylenediaminetetraacetic acid; potassium carbonate; In water; for 0.333333h;

di-tert-butyl dicarbonate; In water; acetone; for 48h;
DOI:10.1016/j.bmcl.2021.128499