(1H-Imidazol-2-yl)methanamine hydrochloride

Base Information

• Chemical Name: (1H-Imidazol-2-yl)methanamine hydrochloride
• CAS No.: 138799-95-8
• Molecular Formula: C4H7 N3 . Cl H
• Molecular Weight: 133.58
• Hs Code.: 2933290090
• DSSTox Substance ID: DTXSID00377800
• Mol file: 138799-95-8.mol

Synonyms:138799-95-8;(1H-Imidazol-2-yl)methanamine hydrochloride;2-aminomethylimidazole hydrochloride;1H-imidazol-2-ylmethanamine;hydrochloride;(1H-imidazol-2-ylmethyl)amine hydrochloride;1H-IMIDAZOL-2-YLMETHYLAMINE HYDROCHLORIDE;1H-Imidazole-2-methanamine, monohydrochloride;1H-Imidazole-2-methanamine, hydrochloride (1:1);SCHEMBL2721069;DTXSID00377800;BVKSLJGZOIDXTK-UHFFFAOYSA-N;MFCD07366514;AKOS004107412;aminomethyl imidazole hydrochloride salt;FS-6048;(1H-IMIDAZOL-2-YL)METHANAMINE HCL;(1H-Imidazol-2-yl)methanaminehydrochloride;CS-0155579;FT-0647660;C72548;A807442;1-(1H-Imidazol-2-yl)methanamine--hydrogen chloride (1/1)

Chemical Property of (1H-Imidazol-2-yl)methanamine hydrochloride

Chemical Property:

• Vapor Pressure: 8.09E-05mmHg at 25°C
• Boiling Point: 341.4°C at 760 mmHg
• Flash Point: 187°C
• PSA: 54.70000
• LogP: 1.37070
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 133.0406750
• Heavy Atom Count: 8
• Complexity: 54.9

Purity/Quality:

98%min ^*data from raw suppliers

(1H-Imidazol-2-yl)methanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(N1)CN.Cl

Technology Process of (1H-Imidazol-2-yl)methanamine hydrochloride

There total 3 articles about (1H-Imidazol-2-yl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(E/Z)-1H-imidazole-2-carbaldehyde oxime (127020-07-9) → (1H-imidazol-2-yl)methanamine dihydrochloride (22600-77-7,138799-95-8)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 3h; under 2585.81 Torr;

DOI:10.1021/jo902588s

Reference yield: 68.0%

1-benzoyl-2-(1,3-dibenzoyl-4-imidazolin-2-yl)imidazole (62457-77-6) → (1H-imidazol-2-yl)methanamine dihydrochloride (22600-77-7,138799-95-8)

Guidance literature:

With hydrogenchloride; isopropyl alcohol; In methanol; for 24h; Heating;

DOI:10.3987/com-02-9608

Reference yield: 62.0%

2-(1H-Imidazol-2-ylmethyl)-isoindole-1,3-dione; hydrochloride (92741-91-8) → (1H-imidazol-2-yl)methanamine dihydrochloride (22600-77-7,138799-95-8) + benzene-1,2-dicarboxylic acid (88-99-3,73607-73-5)

Guidance literature:

With hydrogenchloride; for 8h; Heating;

upstream raw materials:

2-(1H-Imidazol-2-ylmethyl)-isoindole-1,3-dione; hydrochloride

1-benzoyl-2-(1,3-dibenzoyl-4-imidazolin-2-yl)imidazole

(E/Z)-1H-imidazole-2-carbaldehyde oxime

Downstream raw materials:

tert-butyl [(1H-imidazol-2-yl)methyl]carbamate

Refernces

• 1、 Park, Sujin,Kang, Yonghan. "Reactivities of 2-aminomethylimidazole: An approach for a synthesis of imidazo[1,5-a]imidazole". . p. 2393 - 2400. Retrieved 2007/10/03.