5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 138907-72-9
• Molecular Formula: C12H11F2N3O2
• Molecular Weight: 267.235
• Hs Code.: 2933199090
• Mol file: 138907-72-9.mol

Synonyms:5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;BUTTPARK 41\09-24

Chemical Property of 5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Melting Point: 127-128°
• Boiling Point: 375.4±42.0 °C(Predicted)
• PKA: 0.36±0.14(Predicted)
• PSA: 70.14000
• Density: 1.40±0.1 g/cm3(Predicted)
• LogP: 2.49060

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

There total 1 articles about 5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2,4-difluorophenyl)hydrazinium chloride (40594-29-4,51523-79-6) + ethyl (ethoxymethylene)cyanoacetate (94-05-3,42466-69-3) → ethyl 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate (138907-72-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; Heating / reflux;

Reference yield:

ethyl 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate (138907-72-9) → 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid (918405-21-7)

Guidance literature:

ethyl 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate; With sodium hydroxide; ethanol; water; at 70 ℃; for 2.5h;

With hydrogenchloride; In water; pH=7;

Reference yield:

ethyl 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate (138907-72-9) → C12H9F2IN2O2 (1222077-06-6)

Guidance literature:

With iodine; isopentyl nitrite; In chloroform; Reflux;

DOI:10.1016/j.bmcl.2010.01.059

upstream raw materials:

(2,4-difluorophenyl)hydrazinium chloride

ethyl (ethoxymethylene)cyanoacetate

Downstream raw materials:

5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid

C₁₂H₉F₂IN₂O₂