5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid
CAS No.:918405-21-7
Molecular Formula:C10H7F2N3O2
Molecular Weight:239.181
Hs Code.:
DSSTox Substance ID:DTXSID20575588
Wikidata:Q82464984
Mol file:918405-21-7.mol

Synonyms:5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid;918405-21-7;5-amino-1-(2,4-difluorophenyl)pyrazole-4-carboxylic Acid;MFCD03407405;SCHEMBL3376472;DTXSID20575588;BMZMLHXRADPUBF-UHFFFAOYSA-N;AKOS005667593;VS-09534;CS-0237733;EN300-186624

Suppliers and Price of 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid

Chemical Property:

PSA：81.14000
LogP:2.01210
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:239.05063280
Heavy Atom Count:17
Complexity:305

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)F)N2C(=C(C=N2)C(=O)O)N

Technology Process of 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid

There total 1 articles about 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138907-72-9
ethyl 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate

: 918405-21-7
5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: ethyl 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate; With sodium hydroxide; ethanol; water; at 70 ℃; for 2.5h;

With hydrogenchloride; In water; pH=7;

Reference yield:

: C₁₆H₂₂F₃NO

: 918405-21-7
5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid

: C₂₆H₂₇F₅N₄O₂

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.06.066

Reference yield:

: 918405-21-7
5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid

: C₁₉H₂₆F₃NO

: C₂₉H₃₁F₅N₄O₂

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.06.066