L-glycero-D-manno-7-Octulo-7,4-furanosonic acid, 2,7-anhydro-8-deoxy-, (7R)- (9CI)

Base Information

Chemical Name:L-glycero-D-manno-7-Octulo-7,4-furanosonic acid, 2,7-anhydro-8-deoxy-, (7R)- (9CI)
CAS No.:630126-57-7
Molecular Formula:C8H12O7
Molecular Weight:220.18
Hs Code.:
Mol file:630126-57-7.mol

Synonyms:L-glycero-D-manno-7-Octulo-7,4-furanosonic acid, 2,7-anhydro-8-deoxy-, (7R)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-glycero-D-manno-7-Octulo-7,4-furanosonic acid, 2,7-anhydro-8-deoxy-, (7R)- (9CI)

Chemical Property:

PSA：116.45000
LogP:-2.33250

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of L-glycero-D-manno-7-Octulo-7,4-furanosonic acid, 2,7-anhydro-8-deoxy-, (7R)- (9CI)

There total 18 articles about L-glycero-D-manno-7-Octulo-7,4-furanosonic acid, 2,7-anhydro-8-deoxy-, (7R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 630126-56-6
(1R,3S,4S,5R,6R,7R)-4,6,7-Trihydroxy-1-methyl-2,8-dioxa-bicyclo[3.2.1]octane-3-carbaldehyde

: 630126-57-7
(1R,3S,4S,5R,6R,7R)-4,6,7-Trihydroxy-1-methyl-2,8-dioxa-bicyclo[3.2.1]octane-3-carboxylic acid

Guidance literature:: With sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; In tert-butyl alcohol; at 20 ℃;
DOI:10.1016/j.tetlet.2003.09.021

Reference yield:

: 630126-49-7
(2R,3S)-2-Benzyloxy-3-hydroxy-pent-4-enoic acid methoxy-methyl-amide

: 630126-57-7
(1R,3S,4S,5R,6R,7R)-4,6,7-Trihydroxy-1-methyl-2,8-dioxa-bicyclo[3.2.1]octane-3-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 89 percent / Grubbs catalyst / CH₂Cl₂ / Heating

2: 83 percent / MeMgBr / tetrahydrofuran / 0 °C

3: K₂OsO₄*2H₂O; NaClO₃; aq. AcOH / methanol / 20 °C

4: conc. HCl / tetrahydrofuran / 20 °C

5: DMAP; pyridine / CH₂Cl₂ / 20 °C

6: hydrogen / Pd/C / tetrahydrofuran / 20 °C / 760 Torr

7: DMAP; pyridine / CH₂Cl₂ / 20 °C

8: lithium aluminum hydride / tetrahydrofuran / Heating

9: NaIO₄; aq. MeOH / 20 °C

10: aq. NaClO₂; KH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 20 °C

With pyridine; hydrogenchloride; methanol; dmap; sodium chlorate; sodium chlorite; potassium osmate(VI); sodium periodate; potassium dihydrogenphosphate; lithium aluminium tetrahydride; Grubbs catalyst first generation; 2-methyl-but-2-ene; methylmagnesium bromide; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol; 10: Pinnick oxidation;
DOI:10.1016/j.tetlet.2003.09.021

Reference yield:

: 630126-48-6
(4R,5S)-3-((2R,3S)-2-(benzyloxy)-3-hydroxypent-4-enoyl)-4-methyl-5-phenyloxazolidin-2-one

: 630126-57-7
(1R,3S,4S,5R,6R,7R)-4,6,7-Trihydroxy-1-methyl-2,8-dioxa-bicyclo[3.2.1]octane-3-carboxylic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 81 percent / Me₃Al / CH₂Cl₂ / 0 - 20 °C

2: 89 percent / Grubbs catalyst / CH₂Cl₂ / Heating

3: 83 percent / MeMgBr / tetrahydrofuran / 0 °C

4: K₂OsO₄*2H₂O; NaClO₃; aq. AcOH / methanol / 20 °C

5: conc. HCl / tetrahydrofuran / 20 °C

6: DMAP; pyridine / CH₂Cl₂ / 20 °C

7: hydrogen / Pd/C / tetrahydrofuran / 20 °C / 760 Torr

8: DMAP; pyridine / CH₂Cl₂ / 20 °C

9: lithium aluminum hydride / tetrahydrofuran / Heating

10: NaIO₄; aq. MeOH / 20 °C

11: aq. NaClO₂; KH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 20 °C

With pyridine; hydrogenchloride; methanol; dmap; sodium chlorate; sodium chlorite; potassium osmate(VI); sodium periodate; potassium dihydrogenphosphate; lithium aluminium tetrahydride; Grubbs catalyst first generation; 2-methyl-but-2-ene; methylmagnesium bromide; hydrogen; trimethylaluminum; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol; 11: Pinnick oxidation;
DOI:10.1016/j.tetlet.2003.09.021