630126-48-6Relevant academic research and scientific papers
Design and synthesis of an inositol phosphate analog based on computational docking studies
Peng, Zhenghong,Maxwell, David,Sun, Duoli,Ying, Yunming,Schuber Jr., Paul T.,Bhanu Prasad, Basvoju A.,Gelovani, Juri,Alfred Yung, Wai-Kwan,Bornmann, William G.
, p. 984 - 990 (2014)
A virtual library of 54 inositol analog mimics of In(1,4,5)P3 has been docked, scored, and ranked within the binding site of human inositol 1,4,5-trisphosphate 3-kinase A (IP3-3KA). Chemical synthesis of the best scoring structure that also met distance criteria for 3′-OH to-P in phosphate has been attempted along with the synthesis of (1S,2R,3S,4S)-3-fluoro- 2,4-dihydroxycyclohexanecarboxylic acid as an inositol analog, useful for non-invasive visualization and quantitation of IP3-3KA enzymatic activity.
A symmetry-based approach to the heterobicyclic core of the zaragozic acids - Model studies in the C2-symmetric series
Bierstedt, Anja,Roels, Jochen,Zhang, Junliang,Wang, Yuzhou,Fr?hlich, Roland,Metz, Peter
, p. 7867 - 7870 (2007/10/03)
A conceptually novel access to models for the title structures has been achieved by rapid enantioselective construction of polyhydroxy diketones in a two-directional or convergent fashion and group-selective intramolecular acetalization.
