1-[4-(Benzyloxy)phenyl]piperazine

Base Information

• Chemical Name: 1-[4-(Benzyloxy)phenyl]piperazine
• CAS No.: 144881-52-7
• Molecular Formula: C17H20 N2 O
• Molecular Weight: 268.359
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID00370755
• Nikkaji Number: J1.714.564I
• Wikidata: Q82157910
• Mol file: 144881-52-7.mol

Synonyms:1-[4-(benzyloxy)phenyl]piperazine;144881-52-7;1-(4-Benzyloxy-phenyl)-piperazine;1-(4-phenylmethoxyphenyl)piperazine;1-(4-(Benzyloxy)phenyl)piperazine;SCHEMBL335477;DTXSID00370755;BSYHPGDHIZWPSR-UHFFFAOYSA-N;BBL017902;Benzyl 4-piperazin-1-ylphenyl ether;MFCD04113541;STK488710;AKOS003237881;AB17678;VS-06580;CS-0270083;EN300-1865043;A808286

Chemical Property of 1-[4-(Benzyloxy)phenyl]piperazine

Chemical Property:

• PSA: 24.50000
• LogP: 3.06900
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 268.157563266
• Heavy Atom Count: 20
• Complexity: 264

Purity/Quality:

97% ^*data from raw suppliers

1-[4-(benzyloxy)phenyl]piperazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C2=CC=C(C=C2)OCC3=CC=CC=C3

Technology Process of 1-[4-(Benzyloxy)phenyl]piperazine

There total 8 articles about 1-[4-(Benzyloxy)phenyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(4-benzyloxyphenyl)piperazine-1-carboxylic acid tert-butyl ester (943035-30-1) → 1-(4-benzyloxyphenyl)piperazine (144881-52-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1021/jm401384w

Reference yield: 80.0%

piperazine (110-85-0) + p-benzyloxyphenylbromide (6793-92-6) → 1-(4-benzyloxyphenyl)piperazine (144881-52-7)

Guidance literature:

With (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthalene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; toluene; at 80 - 90 ℃; for 3h;

DOI:10.1016/S0040-4039(02)00556-7

Reference yield:

C20H25ClN2O(2+)*2BF4(1-) → 1-(4-benzyloxyphenyl)piperazine (144881-52-7)

Guidance literature:

With water; sodium thiosulfate; In acetonitrile; at 100 ℃; for 2h; Sealed tube;

DOI:10.1038/nchem.2529

upstream raw materials:

piperazine

p-benzyloxyphenylbromide

4-(4-benzyloxyphenyl)piperazine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate

Downstream raw materials:

1-[4-(4-Benzyloxy-phenyl)-piperazin-1-yl]-3-chloro-propan-2-ol

5-[4-(4-Benzyloxy-phenyl)-piperazin-1-ylmethyl]-4,5-dihydro-oxazol-2-ylamine

2-[4-(4-benzyloxy-phenyl)piperazin-1-yl]-4,5-dihydroimidazo[4,5,1-ij]quinolin-6-one ethylene ketal

{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

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