(S)-5-(3-(2-hydroxyethylthio)-5-methoxy-4-propoxyphenyl)dihydrofuran-2(3H)-one

Base Information

Chemical Name:(S)-5-(3-(2-hydroxyethylthio)-5-methoxy-4-propoxyphenyl)dihydrofuran-2(3H)-one
CAS No.:140705-18-6
Molecular Formula:C16H22 O5 S
Molecular Weight:0
Hs Code.:
Mol file:140705-18-6.mol

Synonyms:(S)-5-(3-(2-hydroxyethylthio)-5-methoxy-4-propoxyphenyl)dihydrofuran-2(3H)-one

Suppliers and Price of (S)-5-(3-(2-hydroxyethylthio)-5-methoxy-4-propoxyphenyl)dihydrofuran-2(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (S)-5-(3-(2-hydroxyethylthio)-5-methoxy-4-propoxyphenyl)dihydrofuran-2(3H)-one

Chemical Property:

PSA：90.29000
LogP:2.94650

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-5-(3-(2-hydroxyethylthio)-5-methoxy-4-propoxyphenyl)dihydrofuran-2(3H)-one

There total 3 articles about (S)-5-(3-(2-hydroxyethylthio)-5-methoxy-4-propoxyphenyl)dihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1892-29-1
bis(2-hydroxyethyl) disulfide

: 133095-95-1
4[3-Methoxy-4-n-propyloxy-5-iodophenyl]-4S-butyrolactone

: 140705-18-6
(S)-5-[3-(2-Hydroxy-ethylsulfanyl)-5-methoxy-4-propoxy-phenyl]-dihydro-furan-2-one

Guidance literature:: With copper; In N,N-dimethyl-formamide; at 108 ℃; for 22h;
DOI:10.1021/jo00052a013

Reference yield:

: 133095-94-0
(S)-4-Hydroxy-4-(3-iodo-5-methoxy-4-propoxy-phenyl)-butyric acid

: 140705-18-6
(S)-5-[3-(2-Hydroxy-ethylsulfanyl)-5-methoxy-4-propoxy-phenyl]-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / toluene / 0.75 h / 70 °C

2: 90 percent / copper bronze / dimethylformamide / 22 h / 108 °C

With pyridinium p-toluenesulfonate; copper; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00052a013

Reference yield:

: 133095-92-8
4-(3-Iodo-5-methoxy-4-propoxy-phenyl)-4-oxo-butyric acid tert-butyl ester

: 140705-18-6
(S)-5-[3-(2-Hydroxy-ethylsulfanyl)-5-methoxy-4-propoxy-phenyl]-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1) (-)-chlordiisopinocampheylborane, 2) 5 M aq. NaOH / 1) THF, a) 0 deg C, 4 h, b) 0-5 deg C, 2) methanol, water, 23 deg C, 1.5 h

2: pyridinium p-toluenesulfonate / toluene / 0.75 h / 70 °C

3: 90 percent / copper bronze / dimethylformamide / 22 h / 108 °C

With sodium hydroxide; pyridinium p-toluenesulfonate; copper; (-)-diisopinocamphenylborane chloride; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00052a013