133095-95-1

Upstream product

• 106331-89-9 3-methoxy-4-n-propyloxy-5-iodobenzaldehyde 
• 5438-36-8 5-iodovaniline 
• 133095-93-9 (S)-4-Hydroxy-4-(3-iodo-5-methoxy-4-propoxy-phenyl)-butyric acid tert-butyl ester 
• 133095-92-8 4-(3-Iodo-5-methoxy-4-propoxy-phenyl)-4-oxo-butyric acid tert-butyl ester 
• 133095-94-0 (S)-4-Hydroxy-4-(3-iodo-5-methoxy-4-propoxy-phenyl)-butyric acid 

Downstream Products

• 133095-96-2 (S)-5-(3-Methoxy-5-methylsulfanyl-4-propoxy-phenyl)-dihydro-furan-2-one 
• 135947-75-0 MK 287 
• 140705-19-7 (S)-5-[3-(2-Hydroxy-ethanesulfonyl)-5-methoxy-4-propoxy-phenyl]-dihydro-furan-2-one 
• 141869-80-9 (S)-5-{3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethanesulfonyl]-5-methoxy-4-propoxy-phenyl}-dihydro-furan-2-one 
• 140705-14-2 (2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfonyl)-4-propoxyphenyl]tetrahydrofuran 
• 121702-60-1 L 662418 
• 116781-15-8 (-)-L 659989 
• 133095-90-6 (S)-2-Bromo-5-(3-methanesulfonyl-5-methoxy-4-propoxy-phenyl)-tetrahydro-furan 
• 133095-99-5 (2S,5S)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(2,3,4-trimethoxy-phenyl)-tetrahydro-furan 
• 133117-06-3 (S)-5-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-dihydro-furan-2-one 
• 133095-97-3 (S)-5-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-tetrahydro-furan-2-ol 
• 140705-18-6 (S)-5-[3-(2-Hydroxy-ethylsulfanyl)-5-methoxy-4-propoxy-phenyl]-dihydro-furan-2-one 

Relevant academic research and scientific papers

In-situ preparation of diisopinocamphenyl chloroborane

The present invention is directed to in-situ preparation of diisopinocamphenylchloroborane, and the use of same in the reduction of prochiral ketones to optically active alcohols such as those of formula B. STR1 The compound of Formula B is useful in the production 2,5-diaryltetrahydrofurans useful as PAF antagonists.

Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as PAF antagonists

The present invention is directed to a process of making tetrahydrofuran of the formula (D) STR1 resulting in 2,5-diaryltetrahydrofuran PAF antagonists of pharmaceutically acceptable purity.

Method of making optically active alcohols

The present invention is directed to in-situ preparation of diisopinocamphenyl chloroborane, and the use of same in the reduction of prochiral ketones to optically active alcohols such as those of formula B. The compound of Formula B is useful in the production of 2,5-diaryltetrahydrofurans useful as PAF antagonists.

A practical, one-pot preparation of diisopinocampheylchloroborane

A one-pot preparation of the chiral reducing agent diisopinocampheylchloroborane (Ipc2BCl) from α-pinene and borane methyl sulfide has been developed. The procedure obviates isolation of the air and moisture sensitive reagent, making it useful

A practical, one-pot preparation of diisopinocampheylchloroborane

A one-pot preparation of the chiral reducing agent diisopinocampheylchloroborane (Ipc2BCl) from α-pinene and borane methyl sulfide has been developed. The procedure obviates isolation of the air and moisture sensitive reagent, making it useful for large scale operations. Asymmetric reduction of ketones using the in situ prepared Ipc2BCl is comparable to that using isolated reagent.

Conversion of a silylated hemiacetal into an α-bromoether using trimethylsilylbromide. Synthesis of platelet activating factor antagonist L-659,989

An efficient synthesis of platelet activating factor antagonist L-659,989 has been achieved in ten steps from commercially available 5-iodovanillin. The key transformation converts a silylated hemi-acetal into an α-bromoether followed by a highly stereose