((7R,9AS)-Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol

Base Information

Chemical Name:((7R,9AS)-Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol
CAS No.:145012-51-7
Molecular Formula:C₉H₁₈N₂O
Molecular Weight:170.255
Hs Code.:
DSSTox Substance ID:DTXSID50434452
Wikidata:Q82248878
Mol file:145012-51-7.mol

Synonyms:145012-51-7;((7R,9AS)-OCTAHYDRO-1H-PYRIDO[1,2-A]PYRAZIN-7-YL)METHANOL;764714-59-2;((7R,9aS)-octahydro-2H-pyrido[1,2-a]pyrazin-7-yl)methanol;[(7R,9aS)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl]methanol;cis-(octahydro-pyrido[1,2-a]pyrazin-7-yl)-methanol;rel-((7R,9aS)-Octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol;SCHEMBL3543152;DTXSID50434452;IUKDDYAECHPPRM-BDAKNGLRSA-N;2H-Pyrido[1,2-a]pyrazine-7-methanol,octahydro-,(7R,9aS)-(9CI);AKOS006285259;rel-(7R,9aS)-octahydro-2H-pyrido[1,2-a]pyrazine-7-methanol;(7R,9aS)-7-hydroxymethyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine

Suppliers and Price of ((7R,9AS)-Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
((7R,9aS)-Octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol 95+%
1g
$ 772.00

Chemenu
((7R,9aS)-octahydro-2H-pyrido[1,2-a]pyrazin-7-yl)methanol 95%
1g
$ 729.00

American Custom Chemicals Corporation
((7-R,9-ALPHA-S)-OCTAHYDRO-1H-PYRIDO-[1,2-A]PYRAZIN-7-YL)METHANOL 95.00%
1G
$ 1575.00

American Custom Chemicals Corporation
((7-R,9-ALPHA-S)-OCTAHYDRO-1H-PYRIDO-[1,2-A]PYRAZIN-7-YL)METHANOL 95.00%
5MG
$ 498.65

Alichem
((7R,9aS)-Octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol
1g
$ 628.00

Total 4 raw suppliers

Chemical Property of ((7R,9AS)-Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol

Chemical Property:

PSA：35.50000
LogP:-0.07080
Storage Temp.:2-8°C
XLogP3:-0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:170.141913202
Heavy Atom Count:12
Complexity:152

Purity/Quality:

98%min ^*data from raw suppliers

((7R,9aS)-Octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CN2C1CNCC2)CO
Isomeric SMILES:C1C[C@H](CN2[C@@H]1CNCC2)CO

Technology Process of ((7R,9AS)-Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol

There total 28 articles about ((7R,9AS)-Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 145033-25-6
methyl trans-1-oxo-1,3,4,6,7,8,9,9a-octahydro-2H-pyrido<1,2-a>pyrazine-7-carboxylate

: 145012-50-6,145012-51-7,433734-91-9
(7RS,9aSR)-trans-(octahydropyrido[1,2-a]pyrazin-7-yl)methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

Reference yield:

: 780785-23-1
[2-(toluene-4-sulfonyl)octahydropyrido[1,2-a]pyrazine-7-yl]methanol

: 764714-59-2,145012-50-6,145012-51-7,433734-91-9
((7R,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol

Guidance literature:: With sodium naphthalenide; In 1,2-dimethoxyethane; at -60 ℃;
DOI:10.1021/ja045966f

Reference yield:

: 780784-69-2
(S)-2-cyano-5-dimethylcarbamoyl-2H-pyridine-1-carboxylic acid methyl ester

: 764714-59-2,145012-50-6,145012-51-7,433734-91-9
((7R,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / Pd/C / methanol / 0.25 h / 20 °C

2: H₂; HCl / Pd/C / ethanol / 1 h / 20 °C

3: Et₃N / CH₂Cl₂ / 1 h / 20 °C

4: aq. NaOH / methanol / 1.5 h / Heating

5: NaBH₃CN; acetic acid / methanol / 2.5 h / -20 °C

6: Cs₂CO₃ / acetonitrile / 1 h / Heating

7: BH₃*NH₃; n-BuLi / tetrahydrofuran; hexane / 4 h

8: sodium naphthalenide / 1,2-dimethoxy-ethane / -60 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; borane-ammonia complex; hydrogen; sodium naphthalenide; sodium cyanoborohydride; caesium carbonate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; acetonitrile;
DOI:10.1021/ja045966f