Carbamic acid, [(propylamino)thioxomethyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [(propylamino)thioxomethyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 145012-93-7
• Molecular Formula: C9H18 N2 O2 S
• Molecular Weight: 218.32
• Mol file: 145012-93-7.mol

Synonyms:Carbamic acid, [(propylamino)thioxomethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, [(propylamino)thioxomethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 82.45000
• LogP: 2.57740

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(propylamino)thioxomethyl]-, 1,1-dimethylethyl ester (9CI)

There total 7 articles about Carbamic acid, [(propylamino)thioxomethyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4,-[[[[(Methoxycarbonyl)imino](propylamino) methyl]amino]methyl][1,1'-biphenyl]-2-carboxylic acid, monopotassium salt + di-tert-butyl dicarbonate (24424-99-5) → N-(tert-butoxycarbonyl)-N’-(propyl)thiourea (145012-93-7)

Guidance literature:

With hydrogenchloride; ammonium chloride; In tetrahydrofuran; mineral oil;

Reference yield: 95.0%

propylthiourea (927-67-3) + di-tert-butyl dicarbonate (24424-99-5) → N-(tert-butoxycarbonyl)-N’-(propyl)thiourea (145012-93-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)61092-4

Reference yield: 71.0%

propylamine (107-10-8,42939-71-9) + di-tert-butyl dicarbonate (24424-99-5) + thiourea (17356-08-0) → N-(tert-butoxycarbonyl)-N’-(propyl)thiourea (145012-93-7)

Guidance literature:

thiourea; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.75h;

di-tert-butyl dicarbonate; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 8h;

propylamine; Further stages;

DOI:10.1016/j.tetlet.2011.05.132

upstream raw materials:

propylthiourea

di-tert-butyl dicarbonate

propylamine

thiourea

Downstream raw materials:

1-[1-(tert-butoxycarbonyl)-3-propylguanidino]-4-ethoxybenzene