(R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL

Base Information

• Chemical Name: (R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL
• CAS No.: 141113-41-9
• Molecular Formula: C11H11 F2 N3 O2
• Molecular Weight: 255.224
• Mol file: 141113-41-9.mol

Synonyms:1,2-Propanediol,2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-, (R)-

Chemical Property of (R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL

Chemical Property:

• PSA: 71.17000
• LogP: 0.43640

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL

There total 23 articles about (R)-2-(2,4-DIFLUORFENYL)-3-(1H-1,2,4-TRIAZOOL-1-YL)PROPAAN-1,2-DIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,2,4-Triazole (288-88-0) + (S)-3-chloro-2-(2,4-difluorophenyl)propane-1,2-diol (156570-12-6) → (R)-(-)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1,2-diol (141113-41-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃;

Reference yield: 60.0%

1,2,4-Triazole (288-88-0) + (S)-2-(2,4-difluorophenyl)-1-isobutyryloxy-3-methanesulfonyloxy-2-propanol (173837-73-5) → (R)-(-)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1,2-diol (141113-41-9)

Guidance literature:

With methanol; sodium carbonate; for 15h; Heating;

DOI:10.1016/S0040-4039(01)00425-7

Reference yield: 40.0%

1,2,4-Triazole (288-88-0) + (S)-(2-(2,4-difluorophenyl)oxiran-2-yl)methanol (141113-37-3) → (R)-(-)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1,2-diol (141113-41-9)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; Heating;

DOI:10.1016/S0040-4039(01)00425-7

upstream raw materials:

(S)-(+)-2(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol

1,2,4-Triazole

(S)-(2-(2,4-difluorophenyl)oxiran-2-yl)methanol

(S)-2-(2,4-difluorophenyl)-1-isobutyryloxy-3-methanesulfonyloxy-2-propanol

Downstream raw materials:

(R)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol-1-methanesulfonate

(S)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol-1-methanesulfonate

(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol

1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

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