2-Azabicyclo[3.1.0]hexane-1-carboxylicacid,methylester,(1S)-(9CI)

Base Information

• Chemical Name: 2-Azabicyclo[3.1.0]hexane-1-carboxylicacid,methylester,(1S)-(9CI)
• CAS No.: 145241-93-6
• Molecular Formula: C₇H₁₁NO₂
• Molecular Weight: 141.17
• Mol file: 145241-93-6.mol

Synonyms:2-Azabicyclo[3.1.0]hexane-1-carboxylicacid,methylester,(1S)-(9CI)

Chemical Property of 2-Azabicyclo[3.1.0]hexane-1-carboxylicacid,methylester,(1S)-(9CI)

Chemical Property:

• PSA: 38.33000
• LogP: 0.24020

Purity/Quality:

97% ^*data from raw suppliers

(1S,5R)-2-Aza-bicyclo[3.1.0]hexane-1-carboxylicacidmethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Azabicyclo[3.1.0]hexane-1-carboxylicacid,methylester,(1S)-(9CI)

There total 4 articles about 2-Azabicyclo[3.1.0]hexane-1-carboxylicacid,methylester,(1S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(-)-(2S,3R)-N-benzyloxycarbonyl-2,3-methanoproline methyl ester (145241-92-5) → (-)-(2S,3R)-2,3-methanoproline methyl ester (145241-93-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 0.5h; under 760 Torr; Ambient temperature;

DOI:10.1246/bcsj.65.2668

Reference yield:

(-)-(2S,3R)-N-benzyloxycarbonyl-2,3-methanoproline → (-)-(2S,3R)-2,3-methanoproline methyl ester (145241-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / conc. H₂SO₄ / 20 h / Ambient temperature

2: 69 percent / H₂ / 5percent Pd/C / ethyl acetate / 0.5 h / 760 Torr / Ambient temperature

With sulfuric acid; hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1246/bcsj.65.2668

Reference yield:

(1S,2S)-1-Amino-2-(2-chloro-ethyl)-cyclopropanecarboxylic acid methyl ester; hydrochloride → (-)-(2S,3R)-2,3-methanoproline methyl ester (145241-93-6)

Guidance literature:

With potassium carbonate;

DOI:10.1016/0957-4166(96)00139-5

upstream raw materials:

(-)-(2S,3R)-N-benzyloxycarbonyl-2,3-methanoproline methyl ester

Downstream raw materials:

(-)-(Z)-2,3-methano-L-glutamic acid

2-tert-butyl 1-methyl (1S,5R)-2-azabicyclo[3.1.0]hexane-1,2-dicarboxylate

(1aR,7aS)-N-{3-[4-(4-fluoro-benzyl)-7-hydroxy-5-oxo-1,1a,2,3,4,5-hexahydro-3a,4-diaza-cyclopropano[c]inden-6-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl }-methanesulfonamide

(1S,5R)-2-(4-fluoro-benzylamino)-2-aza-bicyclo[3.1.0]hexane-1-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 145241-93-6 2-Azabicyclo[3.1.0]hexane-1-carboxylicacid,methylester,(1S)-(9CI)

Send

Send

Metric Ton KG G Pound L ML

Send

Send