((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)-METHANOL

Base Information

Chemical Name:((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)-METHANOL
CAS No.:145354-78-5
Molecular Formula:C₉H₁₆O₅
Molecular Weight:204.223
Hs Code.:
Mol file:145354-78-5.mol

Synonyms:[4,4'-Bi-1,3-dioxolane]-2-methanol,2',2'-dimethyl-, [2S-[2a,4a(S*)]]-

Suppliers and Price of ((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)-METHANOL

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)METHANOL 95.00%
5MG
$ 495.95

Total 2 raw suppliers

Chemical Property of ((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)-METHANOL

Chemical Property:

PSA：57.15000
LogP:-0.12830

Purity/Quality:

97% ^*data from raw suppliers

((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (2S,4S,4''R)-2'',2''-Dimethyl[4,4''-bi-1,3-dioxolane]-2-methanol is an intermediate used in the synthesis of Troxacitabine (T805580), which is a nucleoside analogue with potential anticancer activity. Troxacitabine have been studied in patients with refractory lymphoproliferative diseases.

Technology Process of ((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)-METHANOL

There total 1 articles about ((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-1-((2S,4S)-2-Hydroxymethyl-[1,3]dioxolan-4-yl)-ethane-1,2-diol

: 67-64-1
acetone

: 145354-78-5
((2S,4S,4'R)-2',2'-Dimethyl-[4,4']bi[[1,3]dioxolanyl]-2-yl)-methanol

Guidance literature:: With toluene-4-sulfonic acid; Yield given; Ambient temperature;
DOI:10.1016/S0040-4039(00)60890-0

Reference yield:

: 145354-78-5
((2S,4S,4'R)-2',2'-Dimethyl-[4,4']bi[[1,3]dioxolanyl]-2-yl)-methanol

: 145354-81-0
(2S,4S)-2-Benzoyloxymethyl-[1,3]dioxolane-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / Ambient temperature

2: p-TsOH / methanol / Ambient temperature

3: NaIO₄ / RuO₂ / acetonitrile; CCl₄; H₂O / Ambient temperature

With pyridine; sodium periodate; toluene-4-sulfonic acid; ruthenium(IV) oxide; In methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(00)60890-0

Reference yield:

: 145354-78-5
((2S,4S,4'R)-2',2'-Dimethyl-[4,4']bi[[1,3]dioxolanyl]-2-yl)-methanol

: 145354-80-9
Benzoic acid (2S,4S)-4-((R)-1,2-dihydroxy-ethyl)-[1,3]dioxolan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / Ambient temperature

2: p-TsOH / methanol / Ambient temperature

With pyridine; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)60890-0