2-[(TERT-BUTYLDIPHENYLSILYLOXY)METHYL]-1,3-DIOXOLAN-4-ONE

Base Information

• Chemical Name: 2-[(TERT-BUTYLDIPHENYLSILYLOXY)METHYL]-1,3-DIOXOLAN-4-ONE
• CAS No.: 145397-22-4
• Molecular Formula: C20H24 O4 Si
• Molecular Weight: 356.49
• Hs Code.: 2932999099
• Mol file: 145397-22-4.mol

Synonyms:1,3-Dioxolan-4-one,2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-, (?à)-

Chemical Property of 2-[(TERT-BUTYLDIPHENYLSILYLOXY)METHYL]-1,3-DIOXOLAN-4-ONE

Chemical Property:

• Refractive Index: 1.553
• PSA: 44.76000
• LogP: 2.46250

Purity/Quality:

2-[(tert-Butyldiphenylsilyloxy)-methyl]-1,3-dioxolan-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(TERT-BUTYLDIPHENYLSILYLOXY)METHYL]-1,3-DIOXOLAN-4-ONE

There total 2 articles about 2-[(TERT-BUTYLDIPHENYLSILYLOXY)METHYL]-1,3-DIOXOLAN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

glycolic Acid (79-14-1) + (tert-butyldiphenylsilanyloxy)acetaldehyde (115869-43-7) → 2-(tert-Butyl-diphenyl-silanyloxymethyl)-[1,3]dioxolan-4-one (145397-22-4)

Guidance literature:

In 1,2-dichloro-ethane; Heating;

Reference yield:

(Z)-2,2,11,11-tetramethyl-3,3,10,10-tetraphenyl-4,9-dioxa-3,10-disiladodec-6-ene (145365-08-8) → 2-(tert-Butyl-diphenyl-silanyloxymethyl)-[1,3]dioxolan-4-one (145397-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / O₃, Me₂S

2: 80 percent / 1,2-dichloro-ethane / Heating

With dimethylsulfide; ozone; In 1,2-dichloro-ethane;

Reference yield:

2-(tert-Butyl-diphenyl-silanyloxymethyl)-[1,3]dioxolan-4-one (145397-22-4) → 2-(tert-Butyl-diphenyl-silanyloxymethyl)-[1,3]dioxolan-4-ol

Guidance literature:

With lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran; at 0 ℃;

upstream raw materials:

glycolic Acid

(tert-butyldiphenylsilanyloxy)acetaldehyde

(Z)-2,2,11,11-tetramethyl-3,3,10,10-tetraphenyl-4,9-dioxa-3,10-disiladodec-6-ene

Downstream raw materials:

Acetic acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]dioxolan-4-yl ester

1-[(2R,4R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-5-methyl-1H-pyrimidine-2,4-dione