Pyrido[2,3-b]pyrazin-3(2H)-one, 1,4-dihydro-1,6-dimethyl- (9CI)

Base Information

• Chemical Name: Pyrido[2,3-b]pyrazin-3(2H)-one, 1,4-dihydro-1,6-dimethyl- (9CI)
• CAS No.: 689259-31-2
• Molecular Formula: C9H11N3O
• Molecular Weight: 177.20314
• Mol file: 689259-31-2.mol

Synonyms:Pyrido[2,3-b]pyrazin-3(2H)-one, 1,4-dihydro-1,6-dimethyl- (9CI);1,6-DIMETHYL-1,4-DIHYDROPYRIDO[2,3-B]PYRAZIN-3(2H)-ONE

Chemical Property of Pyrido[2,3-b]pyrazin-3(2H)-one, 1,4-dihydro-1,6-dimethyl- (9CI)

Chemical Property:

• PSA: 48.72000
• LogP: 0.92840

Purity/Quality:

1,4-dihydro-1,6-dimethyl-Pyrido[2,3-b]pyrazin-3(2H)-one 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrido[2,3-b]pyrazin-3(2H)-one, 1,4-dihydro-1,6-dimethyl- (9CI)

There total 4 articles about Pyrido[2,3-b]pyrazin-3(2H)-one, 1,4-dihydro-1,6-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

ethyl N-METHYL-N-(6-METHYL-2-NITROPYRIDIN-3-YL)glycinate (689259-30-1) → 1,6-DIMETHYL-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one (689259-31-2)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In ethanol; at 20 ℃; for 2h; under 258.581 Torr;

Reference yield:

6-methyl-2-nitropyridin-3-yl trifluoromethanesulfonate (163083-48-5) + sarcosine ethyl ester hydrochloride (52605-49-9) → 1,6-DIMETHYL-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one (689259-31-2)

Guidance literature:

With triethylamine; In toluene;

Reference yield:

6-methyl-2-nitropyridin-3-yl trifluoromethanesulfonate (163083-48-5) → 1,6-DIMETHYL-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one (689259-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C

With hydrogen; palladium on activated charcoal;

DOI:10.1016/j.bmcl.2005.11.017 DOI:10.1016/j.bmcl.2005.11.008

upstream raw materials:

ethyl N-METHYL-N-(6-METHYL-2-NITROPYRIDIN-3-YL)glycinate

6-methyl-2-nitropyridin-3-yl trifluoromethanesulfonate

sarcosine ethyl ester hydrochloride

6-methyl-2-nitropyridin-3-ol

Downstream raw materials:

1,6-dimethyl-1,2,3,4-TETRAHYDROPYRIDO[2,3-b]pyrazine