Pyrido[2,3-b]pyrazine, 1,2,3,4-tetrahydro-1,6-dimethyl- (9CI)

Base Information

• Chemical Name: Pyrido[2,3-b]pyrazine, 1,2,3,4-tetrahydro-1,6-dimethyl- (9CI)
• CAS No.: 689259-32-3
• Molecular Formula: C9H13N3
• Molecular Weight: 163.21962
• Mol file: 689259-32-3.mol

Synonyms:Pyrido[2,3-b]pyrazine, 1,2,3,4-tetrahydro-1,6-dimethyl- (9CI)

Chemical Property of Pyrido[2,3-b]pyrazine, 1,2,3,4-tetrahydro-1,6-dimethyl- (9CI)

Chemical Property:

• PSA: 28.16000
• LogP: 1.45470

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

1,2,3,4-tetrahydro-1,6-dimethyl-Pyrido[2,3-b]pyrazine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrido[2,3-b]pyrazine, 1,2,3,4-tetrahydro-1,6-dimethyl- (9CI)

There total 4 articles about Pyrido[2,3-b]pyrazine, 1,2,3,4-tetrahydro-1,6-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,6-DIMETHYL-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one (689259-31-2) → 1,6-dimethyl-1,2,3,4-TETRAHYDROPYRIDO[2,3-b]pyrazine (689259-32-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 16h; Heating / reflux;

Reference yield:

6-methyl-2-nitropyridin-3-yl trifluoromethanesulfonate (163083-48-5) → 1,6-dimethyl-1,2,3,4-TETRAHYDROPYRIDO[2,3-b]pyrazine (689259-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: LiAlH₄

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal;

DOI:10.1016/j.bmcl.2005.11.017 DOI:10.1016/j.bmcl.2005.11.008

Reference yield:

ethyl N-METHYL-N-(6-METHYL-2-NITROPYRIDIN-3-YL)glycinate (689259-30-1) → 1,6-dimethyl-1,2,3,4-TETRAHYDROPYRIDO[2,3-b]pyrazine (689259-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C

2: LiAlH₄

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal;

DOI:10.1016/j.bmcl.2005.11.017 DOI:10.1016/j.bmcl.2005.11.008

upstream raw materials:

1,6-DIMETHYL-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one

6-methyl-2-nitropyridin-3-yl trifluoromethanesulfonate

ethyl N-METHYL-N-(6-METHYL-2-NITROPYRIDIN-3-YL)glycinate

6-methyl-2-nitropyridin-3-ol